高分子量细胞角蛋白及前列腺特异性抗原在前列腺腺癌中的表达和意义  

Expression and the role of high molecular weight cytokeratin and prostate specific antigen in prostate adenocarcinoma

作　　者：闫洪涛[1] 杨红[2] 陈照祥[1] 潘慈康[1] 

机构地区：[1]四川省人民医院泌尿外科,成都610071 [2]四川省人民医院病理科,成都610071

出　　处：《医学科技》2001年第3期8-10,共3页

摘　　要：目的:提高对各种前列腺良恶性病变的认识和鉴别诊断水平。方法:采用免疫组织化学染色对213例前列腺良恶性病变组织分别作高分子量细胞角蛋白34BE12和前列腺特异性抗原(PSA)标记,特异地显示前列腺基底细胞并间接了解基细胞层的完整性。结果:前列腺腺癌基底细胞均丢失,而前列腺增生性病变基底细胞绝大多数保存完好,只有少数3级前列腺上皮内肿瘤和非典型性瘤样增生基底细胞不完整。对PSA染色,大多数前列腺腺癌表达低,少数分化好的癌组织呈阳性,而良性前列腺增生组织标本中PSA表达高。结论:研究表明,联合应用高分子量细胞角蛋白34BE12及PSA标记物,在前列腺良恶性病变的鉴别诊断及肿瘤恶性程度的判断中均有很好的应用价值。Objective: In order to understand the characteristics of benign and malignant prostate le-sions and to improve its differential diagnosis. Methods: Expression of high molecular weight cytokeratinmonoclonal antibody 34BE12 and prostate specific-antigen (PSA) were detected by immunohistochemicalmethods in 213 benign and malignant prostate tissues. The basal cells and the integrity of the basal celllayer were observed. Results: It was demonstrated that the basal cell layer was lost in all prostate adeno-carcinomas,but existed in most of the porliferative lesions except some cases of atypical adenomatous hy-perplasia and grade 3 intra epithelial neoplasia in which the basal layers were disrupted. Expression ofprostate specific-antigen in most of prostate adenocarcinomas were higher, but lower in benign prostatichyperplasia. Conclusion. The study showed that the 34BE12 antibody and PSA marker are useful in thedifferential diagnosis of benign and malignant prostate lesions.

关 键 词：前列腺肿瘤 腺癌 角蛋白 前列腺特异性抗原 免疫组织化学染色 

分 类 号：R737.25[医药卫生—肿瘤] R392.11[医药卫生—临床医学]