二苄基锡二硫代氨基甲酸衍生物的合成、表征和性质  

Synthesis, Characteriztion and Properties of Dibenzyltin Derivatives of Dithiocarbamate

作　　者：尹汉东[1] 王勇[1] 马春林[1] 张如芬[1] 

机构地区：[1]聊城师范学院化学系,

出　　处：《有机化学》2001年第12期1122-1125,共4页Chinese Journal of Organic Chemistry

基　　金：教育部高校骨干教师资助计划，山东省自然科学基金

摘　　要：利用二苄基二氯化锡和二硫代氨基甲酸盐反应,合成了13种新的二苄基锡二硫代氨基甲酸衍生物.通过元素分析、红外光谱、核磁共振氢谱和质谱对其结构进行了表征.初步生物活性测试结果表明,该类化合物对KB癌细胞具有一定的抑制活性.Thirteen dibenzyltin derivatives of dithiocarbamate were synthesized by the reaction of dibenzyltin dichloride with dithiocarbamates. their structures were characterized by elementary analysis, IR, H-1 NMR and MS. Preliminary biological tests showed that some of new pounds were active against KB cell line in vitro.

关 键 词：二苄基锡衍生物 二硫代氨基甲酸 合成 抗癌活性 KB癌细胞 二苄基锡二硫代氨基甲酸 表征 

分 类 号：R979.1[医药卫生—药品] O627.42[医药卫生—药学]