乳腺癌与围产期激素水平的生态学研究  

Ecologic Study on Relationship Between Breast Cancer and Pregnant Hormone Levels

作　　者：徐飚[1] 俞顺章[1] 李旭亮[1] 汤明荣 宋月华 胡晓敏[4] 法金生[5] 

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]上海南汇县周浦医院 [3]上海国际和平妇婴保健院 [4]复旦大学附属妇产科医院 [5]上海市第二人民医院

出　　处：《中国公共卫生》2001年第11期983-985,共3页Chinese Journal of Public Health

摘　　要：目的　探讨乳腺癌发病率的地域差异与女性胎儿乳腺组织发育过程中宫内激素水平的关系。方法　采用生态学研究方法 ,以乳腺癌发病率较高的波士顿白种妇女 (30 4)和乳腺癌发病率较低的上海妇女 (334例 )为对象 ,比较两地妇女在第16和 2 7孕周时与妊娠有关的各种激素水平的差异。结果　上海妇女除了第 2 7孕周时孕激素水平较低外 ,其余各激素在第 16和 2 7孕周时均明显高于波士顿妇女 ,且差别有极显著意义 (P <0 0 1)。结论　乳腺癌发病率迥异的中美孕妇 。Objective To study the relationship between the geographical variation in breast cancer incidence and the difference of pregnant hormone levels which form the intrauterine hormonal millen for the offspring.Methods An ecological study is used to compare the pregnancy hormone levels in a population with high breast cancer incidence(Boston,304 subjects)with a population in a low incidence(Shanghai,334 subjects).To compare the level of pregnancy hormones at weeks of 16 and 27 between the two places.Results Shanghai women have higher serum levels on almost all studied pregnancy hormones at weeks 16 and 27 of gestation except the low level of pregnancy hormone at 27 weeks,and the differences of hormone levles between women have statistical significance.Conclusion The differences of hormone levels between US Caucasian and Shanghai women are reasonable to explain the remarkable difference of breast cancer incidences between them.

关 键 词：生态学研究 妊娠期激素 乳腺癌 发病率 病因 

分 类 号：R737.902[医药卫生—肿瘤]