脑梗塞家族聚集性的研究  

Study on Familial Aggregation in Arteriosclerotic Cerebral Infarction

作　　者：赵景波[1] 刘文川[1] 冯红旗[1] 成旭[1] 徐双[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,150001

出　　处：《中国公共卫生》2001年第11期998-999,共2页Chinese Journal of Public Health

摘　　要：目的　研究脑梗塞是否存在家族聚集性。方法　采用病例对照研究 ,对哈尔滨市 95个脑梗塞先证家系和 95个对照家系进行了脑梗塞家族史的遗传易感性的研究。结果　病例和对照家系年龄及性别有良好的均衡 ,病例组一级亲属总的患病率为 16 94% ,与对照组的 3 70 %相比 ,有显著性差异 (χ2 =81 32 ,P <0 0 1) ,不论其父母或同胞 ,均以病例亲属的患病率显著高于对照 ,而子女两者无显著性差异 ;二项分布分析显示 ,脑梗塞家族中实际发病数超过其二项分布的理论概率范围 ,即脑梗塞的分布呈明显的家族聚集性 ;单因素和多因素Logistic回归模型拟合也提示 ,遗传因素在脑梗塞发病中有重要地位。Objective To Study the farmilial aggregation in arterioscerotic cerebral infarction.Method A case control study including pedigrees(95 cases and 95 controls) was carried out to explore the etiology of family aggregation of artriosclerotic cerebral in farction in harbin city.Results The family members in both cases and control groups were comparable.The total prevalence rate of the first pedigree relatives in cases was 16.94%,significantly higher than (3.70%) that noticed in controls,with χ 2=81 32(P<0 01) .The same results was also found in their parents and siblings.Results from binominal distribution analysis showed that the number of cases in the farmilies of arteriosclerotic cerebral infarction was significanlty higher than the therotical range,which indicated that there was significant familial aggregation in the occurance of artcrioselerotic cerebral infarction.Logistic regression model also showed that genetic factor was one of the most important risk factors in harbin city.Dose response was observed in this model.Conclusion There was familial aggregation in arteriosclerotic cerebral infarction.

关 键 词：脑梗塞 家族聚集性 病因 遗传因素 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]