类高雪氏细胞在慢性粒细胞白血病中的意义  

PSEUDO-GAUCHER CELLS BONE MARROW FROM PATIENTS WITH CHRONIC MYELOCYTIC LEUKEMIA

作　　者：谭春艳[1] 任咏薇[1] 覃桂芳[1] 杨霞芳[1] 李伟平[1] 杜武杰[1] 

机构地区：[1]广西壮族自治区人民医院,南宁530021

出　　处：《中国现代医学杂志》2001年第12期31-32,共2页China Journal of Modern Medicine

摘　　要：目的 :探讨慢性粒细胞白血病 (CML)骨髓中出现类高雪氏细胞的意义。方法 :利用形态学及细胞化学染色检查 94例CML患者和 6 3例类白血病反应患者的骨髓涂片 ;检测 49例CML患者骨髓的Ph染色体 ;分析94例CML患者出现急变期或加速期的情况。结果 :94例CML患者的骨髓涂片中有 2 9例找到类高雪氏细胞 ,而类白血病反应患者的骨髓涂片中未找到类高雪氏细胞 ;CML患者Ph染色体的阳性率为 91.8%(4 5 / 49) ;6 5例无类高雪氏细胞的CML有 2 1例处于急变期或加速期 (急性期 17例 ,加速期 4例 ) ,而 2 9例有类高雪氏细胞的CML有 2例发生急变 ,两组间有显著差异 (P <0 .0 1)。结论Objective:To evaluate the significance of pseudo-Gaucher cells in the bone marrow from patients with chronic myelocytic leukemia (CML).Methods:We examined 157 bone marrow slides(94 from patients with CML and 63 from patients with leukemoid reaction) by morphometry and cytochemistry stain. The Philadelphia chromosome(Ph) was detected in the bone marrow in 49 patients with CML.A study was performed on the CML cases in blast phase and accelerated phase.Results:Pseudo-Gaucher cells were found in the bone marrow in 29 of 94 cases with CML;however,it was not found in the bone marrow in 63 cases with leukemoid reaction.The Ph-positive ratio was 91.8%(45/49).Blast phase or accelerated phase appeared in 21 of 65 CML cases without Pseudo-Gaucher cell and 2 of 29 CML cases with Pseudo-Gaucher cell,and there were significant differences between the two groups( P <0.01).Conclusions:Pseudo-Gaucher cells are of great value to the diagnosis and prognosis of CML.

关 键 词：慢性粒细胞白血病 类高雪氏细胞 中性粒细胞碱性磷酸酶 PH染色体 

分 类 号：R733.720.2[医药卫生—肿瘤]