急性髓性白血病细胞共表达P-170蛋白和热休克蛋白27的意义  

Involvement of coexpression of P-170 protein and heat shock protein 27 in acute myeloid leukemia

作　　者：何明生[1] 陈燕[1] 吴裕丹[1] 向建平[1] 李慧玉[1] 

机构地区：[1]同济医科大学附属协和医院血液病研究所

出　　处：《临床血液学杂志》2001年第5期200-201,共2页Journal of Clinical Hematology

摘　　要：目的 :研究急性髓性白血病 (AML )细胞共表达 P- 170蛋白和热休克蛋白 2 7(HSP2 7)的意义。方法 :选择初发 AML患者 10例和复发 AML患者 18例 ,用碱性磷酸酶抗碱性磷酸酶 (APAAP)的方法检测 P- 170蛋白和 HSP2 7共表达情况。结果 :共有 11例白血病患者 (初发 AML 患者 1例和复发 AML 患者 10例 )共表达 P-170蛋白和 HSP2 7例 ,两组比较差异有显著性意义 (P <0 .0 5 )。结论 :AML 细胞共表达 P- 170蛋白和 HSP2 7与 AML 的耐药和复发有关 ,两种蛋白共表达比两种蛋白单独表达更有临床意义。Objective:To investigate implication of coexpression of P 170 protein and heat shock protein (HSP) 27 in acute myeloid leukemia.Method:10 untreated and 18 relapsed AML patients were elected,and coexpression of P 170 protein and HSP 27 was detected by alkaline phosphatase antialkaline phosphatase (APAAP) assay.Result:Eleven patients,one patient with untreated AML and 10 patients with relapsed AML,were coexpression of P 170 protein and HSP 27.There was statistical significance to make a comparison with two groups (P< 0.05 ).Conclusion:Coexpression of them was associated with drug resistance and recurrence in AML.It was clinically valuable,compared with only one protein,P 170 or HSP27.

关 键 词：急性白血病 P-170蛋白 热休克蛋白 耐药 

分 类 号：R733.71[医药卫生—肿瘤]