增殖细胞核抗原与喉癌生物学行为相关性的研究  

The relationship between proliferating cell nuclear antigen and laryngeal carcinomas

作　　者：王惠忠[1] 张信行 李成香 张梅 栾信庸[1] 

机构地区：[1]山东大学齐鲁医院,,济南250012 [2]临沂医专 [3]山东侨联医院

出　　处：《山东医大基础医学院学报》2001年第6期321-325,共5页

摘　　要：目的：探讨增殖细胞核抗原（ＰＣＮＡ）表达与喉癌生物学行为的相关性。方法：采用流式细胞免疫法检测４０例喉鳞状细胞癌患者ＰＣＮＡ的表达，同时检测８例癌旁组织作为对照。结果：高中分化鳞癌与低分化鳞癌差异有高度显著性（Ｐ＜０．０１），淋巴结转移阳性组与阴性组差异有显著性　（Ｐ＜０．０５），早期组（Ⅰ，Ⅱ）与晚期组（Ⅲ，Ⅳ）差异无显著性（Ｐ＞０／０５），癌组织与癌旁组织间ＰＣＮＡ指数差异有高度显著性（Ｐ＜０．００１）。结论：ＰＣＮＡ表达与喉癌的病理分级、淋巴结转移呈显著正相关，与临床分期无关，ＰＣＮＡ高表达是喉癌的重要生物学特征。Objective:To study the correlation between the expression of proliferating cell nuclear antigen(PCNA) and laryngeal carcinomas.Methods:The expression of PCNA in 40 squamous cell carcinomas of larynx and 8 adjacent normal tissues were studied with flow cytometricimmunology.Results:The difference was high significant between cell moderate and poor differentiated squamous cell carcinomas (P＜0.01).There was difference between lymph node metastasis and negative lymph node (P＜0.05),but no difference between early and late stages (P＞0.05).The difference of PCNA expression was more significant between carcinomas and adjacent tissues (P＜0.001).Conclusion:The expression of PCNA is strong correlated both with histological grade and lymph node metastasis,but no correlation between PCNA and clinical stages.High expression of PCNA is an important biologic characteristics in laryngeal carcinomas.

关 键 词：喉肿瘤 基因表达 流式细胞术 

分 类 号：R739.650.2[医药卫生—肿瘤]