慢性胃炎胃粘膜细胞凋亡的检测及意义  

The significance of epithelial cell apoptosis in chronic gastritis

作　　者：郝志明[1] 苌新明[1] 吴玉娥[1] 罗金燕[2] 

机构地区：[1]西安交通大学第一医院 [2]西安交通大学第二医院,西安710061

出　　处：《胃肠病学和肝病学杂志》2001年第4期352-353,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　检测慢性胃炎各阶段粘膜细胞凋亡状况并探讨其意义。方法　用TUNEL法检测 6例正常胃粘膜、5 4例慢性浅表性胃炎 (CSG)及 2 8例慢性萎缩性胃炎 (CAG)患者胃粘膜上皮细胞凋亡状况。结果　凋亡指数 (AI)CSG >CAG >正常胃粘膜 (P<0 0 5 ) ,而且炎症粘膜凋亡细胞分布与正常有所不同 ;在CAG ,AI在肠化区 <非肠化区。结论　细胞凋亡在CAG粘膜萎缩及肠化发生中起重要作用。CAG粘膜AI下降可能与胃癌发生有关。Aim To investigate the significance of gastric epithelial cell apoptosis in each stage of chronic gastritis.Method Apoptotic cells were detected by TUNEL in the gastric antral mucosa from 6 normal controls,54 patients with chronic superficial gastritis(CSG)and 28 patients with chronic atrophic gastritis(CAG) Results Apoptosis index(AI) in CSG was significantly higher than that in CAG(16 5±4 1vs 11 3±3 9, P <0 01)and in CAG it was significantly higher than that in normal controls(11 3±3 9 vs 3 3±2 8, P <0 01) Furthermore,the distribution of apoptotic cells in chronic gastritis was different from that in normal controls.AI in non metaplastic areas was significantly higher than that in intestinal metaplastic areas of CAG.Conclusions Apoptosis plays an important role in the development of CAG,and the decrease of AI in atrophic mucosa may contribute to the development of gastric carcinoma.

关 键 词：细胞凋亡 慢性胃炎 检测 病理 诊断 

分 类 号：R573.3[医药卫生—消化系统]