抗转移基因nm23-H1在多发性肝癌中的表达  

Expression of Antimetastatic Gene nm23-H1 in Patients With Multiple Hepatocellular Carcinoma

作　　者：马文锋[1] 翟秀岩[2] 长堀薰 松本由朗 

机构地区：[1]中国医科大学第一临床学院外科,沈阳110001 [2]中国医科大学基础医学院发育生物学研究室 [3]山梨医科大学附属医院第一外科

出　　处：《中国医科大学学报》2001年第6期421-422,共2页Journal of China Medical University

摘　　要：目的 :了解nm2 3 H1基因的表达与多发肝癌临床病理和预后的关系。方法 :30例多发性肝癌选自日本山梨医科大学第一外科的手术病例。组织切片按常规免疫组织化学ABC法染色。结果 :13例为阳性染色 ,17例为阴性染色。两染色组之间 ,肿瘤大小 包膜形成及浸润 侵及浆膜 肝内血管和胆管以及分化程度等方面没有显著性差异。两组相比有显著性差异的是阴性组的肝癌占据肝两叶者常见 (70 .6 % ) ,肝内转移癌居多 (76 .5 % ) ,3年生存率较低 (18.7% )。结论 :nm2 3Objective: The purpose of this study was to investigate the association between the expression of gene nm23 H1 and prognosis, clinicopathology of patients with multiple hepatocellular carcinoma(HCCs). Methods: Thirty cases of multiple HCCs were selected from the First Department of Surgery, Yamanashi Medical University, in Japan. The tumors in all patients were macroscopically resected. The paraffin sections were stained with ABC method of immunohistochemistry. Results: Thirteen cases were positive and 17 cases were negative staining. The difference between negative and positive staining groups was not statistically significant in tumor size, capsule formation,capsule invasion,serosal infiltration, vascular invasion, bile duct invasion and cell differentiation as classified by Edmondson. Negative staining group had higher incidence of Stage IVA(P<0.01), intrahepatic metastasis(P<0.025) and worse prognosis of patients with multiple HCCs (P<0.025)than positive staining group. Conclusion: The expression of nm23 H1 may play an important role in calculation of malignant degree and prognosis of patients with multiple HCCs.

关 键 词：NM23-H1 抗转移基因 多发性肝癌 

分 类 号：R735.703[医药卫生—肿瘤] R730.231.3[医药卫生—临床医学]