HPV感染在新疆食管癌发生中的病理生物学意义  

Detection of HPV infection in esophageal carcinoma of the different nations in Xinjiang and its biopathological significance

作　　者：赵春芳 韩新军 陈朝伦[3] 

机构地区：[1]新疆包虫病临床研究所 [2]新疆公安边防总队医院外科 [3]新疆医科大学第一附属医院病理科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2001年第4期320-321,共2页Journal of Xinjiang Medical University

摘　　要：目的 :了解人乳头瘤病毒 (HPV)感染在新疆不同民族食管癌发生、发展中的作用 ,为探索该病的有效防治提供理论依据。方法:应用 PCR技术对 82例新疆不同民族食管癌石蜡包埋组织标本进行 HPV16 /18蛋白的检测。 结果 :82例食管鳞癌中 HPV16 /18总阳性率为 35 .37% (2 9/82 ) ,其中 HPV16阳性率为 2 3.17% (19/82 ) ,HPV18阳性率为 12 .19% (10 /82 ) ;维吾尔族 HPV感染率较高 ,为 6 1.90 % (13/2 1) ,与哈萨克族 30 .43% (7/2 3)、汉族 2 5 .0 0 % (8/32 )相比具有显著性差异 (P均 <0 .0 5 )。 结论:新疆食管癌发生可能与 HPV感染有关。Objective: To understand the role of HPV infection on the development of esophageal carcinoma in different nations in Xinjiang, it may offer a theoretical base for the prevention and therapy to this cancer. Methods: The infection of HPV type 16 and 18 on paraffin embedded tumor tissues by PCR in 82 patients with esophageal carcinoma (Uygur 21, Han 23, Hazak 32 and other nations 6) were dectected. Results: The total positive frequency of HPV type 16/18 was 35%(29/82),type 16 and 18 in tumor tissues was 23%(19/82) and 12%(10/82) respectively. The detected rate was higher in Uygur patients (62%) than in other nations (P<0.05). Conclusions: HPV may be an important etiologic agent for esophageal carcinogenesis in Xinjiang, especially in Uygur people.

关 键 词：食管鳞状细胞癌 人乳头瘤病毒 PCR 新疆 

分 类 号：R730.261[医药卫生—肿瘤] R735.1[医药卫生—临床医学]