血清AFP、β-HCG、CA-125、CEA、SA联合检测对卵巢恶性肿瘤诊断意义的探讨  

THE STUDY OF DIAGNOSTIC SIGNIFICANCE OF OVARY MALIGNANT TUMOR BY USING AFP,β-HCG,CA-125,CEA AND SA IN THE SERUM

作　　者：刘新义[1] 王平辉[1] 王尔东[1] 刘康龙[1] 何长清[1] 李穗生[1] 汪秋菊[1] 崔金城[1] 

机构地区：[1]湖南省肿瘤医院,湖南长沙410006

出　　处：《肿瘤研究与临床》2001年第5期326-328,共3页Cancer Research and Clinic

摘　　要：目的 :探讨 AFP、β- HCG、CA - 12 5、CEA、SA单项及联合检测对卵巢恶性肿瘤的诊断价值。方法 :182例卵巢恶性肿瘤患者 RIA、IRMA、分光光度计比色测出 AFP、β- HCG、CA- 12 5、CEA、SA血清中的含量。结果 :恶性生殖细胞瘤 AFP、β- HCG血清含量高于恶性上皮细胞瘤及性索 -间质细胞瘤 (P<0 .0 1) ;恶性上皮细胞瘤 CA-12 5高于恶性生殖细胞瘤及性索 -间质细胞瘤 (P<0 .0 1) ;恶性卵巢肿瘤各细胞类型 CEA、SA无显著性 (P>0 .0 5 ) ;CA - 12 5 、 期阳性率 (97.7% )高于 期、 期 (6 3.5 % ) ;5项指标联合检测阳性率 87.6 % ,AFP、β- HCG、CA- 12 5联合检测阳性率 84.9% ;CA - 12 5对浆液性囊腺癌、低分化腺癌敏感性接近 10 0 %。结论 :AFP、β- HCG、CA - 12 5联合检测卵巢恶性肿瘤有较高敏感性、特异性和准确性。 CEA、SA阳性率、特异性较低。Objective:In order to study the diagnosis value of ovary malignant tumor by using AFP,β HCG,CA 125,CEA and SA separately and combinedly.Methods:182 cases with ovary malignant tumor tested for the content of AFP,β HCG,CA 125,CEA and SA in the serum using RIA,IRMA by colorimetric spectrophotometer.Results:The content of serum AFP,β HCG in the germ cell carcinoma is higher than that in the epithelial carcinoma and sex cord stromal cell carcinoma( P <0.01),CA 125,in the epithelial carcinoma is higher than that of germ cell carcinoma and sex cord stromal carcinoma( P <0.01),there is no significant difference of CEA and SA among each types of ovary malignant tumors( P >0.05).The positive rate of CA125 in cases with stage Ⅲ and Ⅳ is 97.7%,and is higher than that of stage Ⅰ,Ⅱ(63.5%).The postive rate of combined testing of 5 index is 87.6%,positive rate of AFP,β HCG and CA 125 of combined testing is 84.9%,CA125 sensitive to serous cystadenocarcinoma and low different adenocarcinoma were nearly 100%.Conclusion:The combined testing of AFP,β HCG and CA125 to ovary carcinoma suggested a higher sensitivity,speciality and accuracy.But the positive rate,speciality of CEA,SA were lower.

关 键 词：CA-125抗原 卵巢恶性肿瘤 血清 诊断 

分 类 号：R737.31[医药卫生—肿瘤]