乳腺癌ER、PR与癌组织其它因素的相关性  

EXPRESSION OF ER AND PR IN BREAST CARCINOMA AND THEIR RELATIONSHIP WITH OTHER FACTOR OF CARCIONMA

作　　者：郭培民[1] 温黎[1] 曲保清[1] 曹立群[1] 

机构地区：[1]山东省德州市人民医院,山东德州253014

出　　处：《肿瘤研究与临床》2001年第5期332-333,共2页Cancer Research and Clinic

摘　　要：目的 :探讨乳腺癌 ER、PR与癌组织的组织学类型、核分极、纤维间质增生及患者年龄等因素的关系。方法 :用免疫组织化学方法 (S- P)检测 ER、PR在 38例乳腺癌中的表达 ,并分析与癌组织诸因素的关系。结果 :38例乳腺癌共有 ER阳性 19例、PR阳性 18例 ,ER、PR均阳性 2 0例 ,C- er B- 2阳性 14例。结论 :ER、PR在老年患者、分化好的细胞核、癌组织有明显的纤维间质增生 ,显示较高的阳性率 ,而在髓样癌、粉刺性导管癌中往往显示很低的阳性率 ,ER、PR的阳性率与 C- er B- 2的阳性率呈反变关系 ,C- er B-Objective:To investigate the relationship among ER,PR of breast carcinoma and histological type,karyon grading,stromal responsive fibrosis,and the age of the patient.Methods:Immunohistochemical method (S P) was used to detect the ER,PR expression in 38 cases of breast carcinoma and analyze their correlation with the factor of breast carinoma.Results:There were 19 cases ER expression,18 cases PR expression,20 cases ER,PR expression in 38 cases of breast carcinoma.Conclusion:The expression of ER,PR were higher in the old patient,well differentiated karyon,marked stomal responsive fibrosis,while were lower in classical medullary carcinoma and comedo intraductal carcinoma the rate of ER,PR expression were reversed with the rate of rate C erB 2 expression,and the of C erB 2 expression were reversed with the histological grading of breast carcinoma.

关 键 词：乳腺癌 ER PR 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]