绝经后生殖系统恶性肿瘤患者骨代谢的变化  

Changes of bone metabolism in postmenopausal patients with malignant genital tumor

作　　者：周容[1] 杨延林[1] 熊庆[1] 陈德才 方芳[1] 邱东生[1] 东云华[3] 曹泽毅[1] 

机构地区：[1]华西医科大学附属二院妇产科,成都610041 [2]华西医科大学附属一院内分泌科,成都610041 [3]华西医科大学基础医学院测试中心,成都610041

出　　处：《中国实用妇科与产科杂志》2001年第8期482-483,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨绝经后生殖系统恶性肿瘤患者骨代谢的变化。方法　分别采用放射免疫法、Behr’s法及ACP酶学测定法检测了 32例自然绝经患者 (绝经组 )和 32例自然绝经后发生女性生殖系统恶性肿瘤患者 (肿瘤组 )血清雌二醇 (E2 )、骨性碱性磷酸酶 (bonealkalinephosphatase ,BALP)和抗酒石酸酸性磷酸酶 (tartrateresistentacidphosphatase ,TRAP)浓度。 结果　绝经组与肿瘤组血清E2 浓度无显著差异 (P >0 0 5 )。肿瘤组血清BALP显著低于绝经组 (P <0 0 5 )。绝经组与肿瘤组血清TRAP无显著差异 (P >0 0 5 )。Objective To investigate the changes of bone metabolism in postmenopausal women with malignant genital tumor.Methods Thirty-two postmenopausal women (postmenopause group)and thirty-two postmenopausal women with malignant tumor (tumor group)were studied.The serum estradiol(E 2),bone alkaline phosphatase(BALP)and tartrate-resistent acid phosphatase (TRAP)levels were detected by RIA,Behr's and ACP method,respectively.Results There was no significant difference of the serum E 2 level between postmenopause and tumor group(P>0 05).The serum BALP level in tumor group was lower than that in the postmenopause group(P<0 05)and no significant difference of the serum TRAP level was seen between postmenopause and tumor group(P>0.05).Conclusion The changes of bone metabolism in postmenopausal patients with malignant tumor are more serious than those of without.

关 键 词：绝经 肿瘤 雌二醇 骨性碱性磷酸酶 抗酒石酸酸性磷酸酶 

分 类 号：R737.302[医药卫生—肿瘤]