羟基喜树碱联用氟脲嘧啶/醛氢叶酸治疗晚期大肠癌的临床研究  

Preliminary Clinical Study on HCPT Combined with Leucovorin and5-FU in Treating Patients with Advanced Colorectal Carcinoma

作　　者：谢德荣[1] 彭杰文[2] 陈岱佳[1] 张惠宜[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院肿瘤科,广州市510120 [2]广东省中山市人民医院肿瘤科

出　　处：《中国肿瘤临床》2001年第10期764-766,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:观察羟基喜树碱(hydroxycamptothecin,HCPT)与醛氢叶酸(leucovorin,LV)、氟脲嘧啶(fluorouracil,5-FU)组成的HLF方案对晚期大肠癌的疗效及不良反应。方法:治疗组27例予HLF方案化疗,HCPT6～8mg/m2,第1～5天静滴;LV20mg/m2,第1～5天静注;5-FU425mg/m2,第1～5天静注。对照组35例予Mayo方案化疗,LV及5-FU用法同治疗组。以上方案每4周重复。结果:HLF方案和Mayo方案有效率、疾病进展时间(timetoprogression,TTP)分别为29.6%vs22.9%(P=0.546)和29.0周vs22.0周(P=0.0238)。主要不良反应为消化系统、血液系统毒性,多为Ⅰ～Ⅱ度,患者耐受良好。结论:HLF方案治疗晚期大肠癌,可能有助于提高有效率、延缓疾病进展,值得临床进一步观察研究。Objective:To observe the therapeutic effects and toxicity of HLF(HCPT/LV/5-FU)regimen in treating patients with advanced colorectal carcinoma.Methods:Twenty-seven patients with advanced colorectal carcinoma were treasted with HLF regimen(HCPT6～8mg /m 2 ,LV20mg /m 2 and5-FU425mg /m 2 daily for5days)and35cases treated with Mayo regimen,all repeated every4weeks.Results:The response rste was29.6%in HLF regimen and22.9%in Mayo regimen(P=0.546),and the time to progression(TTP)was29weeks in the HLF group and22in the Mayo one(P=0.0238).The main toxicity was gastrointestinal reaction and myelosup-pression.All the side effects were mild and tolerable.Conclusion:HLF regimen may be promising for treating advanced colorectal carcinoma,it is worthy of further clinical trail.

关 键 词：晚期大肠癌 化学疗法 羟基喜树碱 醛氢叶酸 氟脲嘧啶 

分 类 号：R735.34[医药卫生—肿瘤]