卡马西平治疗儿童癫痫的血药浓度监测与合理用药  

Monitoring serum concentration of carbamazepine and rational administfation for remedy of epileptic children

作　　者：江秀华[1] 唐薇[1] 秦光明[2] 

机构地区：[1]昆明医学院第一附属医院药剂科,650032 [2]昆明医学院法医学系毒药物分析教研组,650031

出　　处：《儿科药学》2001年第4期21-22,共2页Journal of Pediatric Pharmacy

摘　　要：目的:研究儿童癫痫患者服用卡马西平后,其血药浓度、给药剂量及给药时间的关系。方法:对服用卡马西平及联合用其他抗癫痫药物的51例癫痫患儿,用荧光偏振免疫法(FPIA)监测其血药浓度,并结合疗效进行统计分析。结果:稳态血药浓度与给药剂量、给药时间、是否联合用药等有着密切的关系。结论:儿童癫痫患者服用卡马西平后的血药浓度个体差异大,及时监测血药浓度、调整给药剂量及给药时间,对控制儿童癫痫发作有重要意义。Aim: To study the relation between carbamazepine concentration in serum and administration dosage and interval in epileptic children. Methods: The drug serum concentration of 51 epileptic children including administrating carbamazepine alone or associated with other epileptic drugs were determined by fluorescence polarization immunoassay (FPIA). The results were processed with statistics, linking with curative effect. Results: There is a close relation between the drug serum concentration in stable state and the administration dosage, interval and weather associated with other epileptic drugs. Conclusons: There exists big individual variance among the drug serum concentrations of epileptic children after administrated carbamazepine. It is important for controlling children epilepsy to monitoring the drug serum concentration in time, adjusting administration dosage and interval.

关 键 词：卡马西平 血药浓度 合理用药 儿童 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R748[医药卫生—临床医学]