联合应用白介素2和α干扰素对肝癌术后患者免疫机能的影响  

Increasing the Immunofunction of the Postoperative Patients with Hepatic Cancer by Using IL-2 and IFN-α

作　　者：张一心[1] 陈拓[1] 姜胜华[1] 王庆庆[1] 尤其邑[1] 

机构地区：[1]南通医学院附属医院肿瘤外科,南通226001

出　　处：《中国临床医学》2001年第5期471-472,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :通过在白介素 2 (IL - 2 )和α-干扰素 (IFN -α)治疗原发性肝癌术后患者过程中测定血清白介素 12 (IL - 12 )水平和外周血淋巴细胞表型的变化 ,评价其对患者免疫机能的影响。方法 :将 5 0例原发性肝癌术后患者随机分成两组 :一组给予IL - 2和α -IFN、另一组为对照组。用药前、后分别测定血清白介素 - 12以及流式细胞仪测定淋巴细胞的表型。结果 :用药后血清白介素 - 12及CD3+ 、CD4+ 、CD8+ 、CD5 6 + 比用药前明显升高 (P <0 .0 5 )。结论 :IL - 2和α -INF治疗后内源性IL- 12分泌增加可诱发抗肿免疫 ,改善机体免疫机能。Objective: To evaluate the effect on the immunofunction of postoperative patients with primary hepatic cancer by the change of serum IL-12 level and peripheral lymphocytes express types during the treatment of those hepatic cancer patients with IL-2 and IFN-α and to evaluate the correlation between IL-12 and IL-2. Methods: Fifty postoperative patients of PHC were divided into two groups at random. IL-12 and IFN-α were injected in one group patients. The other group was for controll. Before and after injections the serum IL-12 levels and peripheral lymphocytes express types were separately tested. Results: The mean serum IL-12 level after injection was significantly higher than that before injection( P < 0.05 ). We also found CD3 +,CD4 +,CD8 +,CD56 + were higher significantly after injection. Conclusion: After treated by IL-12 and IFN-α, the IL-12 level was higher and the expressions of CD3 +?CD4 +CD8 +?CD56 + were increased, which suggests immunofunctions is improved.

关 键 词：肝癌 免疫疗法 IL-2 INF-Α IL-12 Α干扰素 

分 类 号：R735.705[医药卫生—肿瘤] R730.51[医药卫生—临床医学]