钙稳态失衡与癌细胞抑制  

Disequilibrium of Calcium Homeostasis and Inhibition of Cancer Cell

作　　者：孙恩杰[1] 闫玉华[1] 徐运华[1] 

机构地区：[1]武汉理工大学理学院,武汉430070

出　　处：《生物化学与生物物理进展》2001年第5期635-638,共4页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目 (3 9770 2 2 5 )~~

摘　　要：细胞胞浆钙离子浓度必须处于严格的调控之中 ,钙稳态失调必将导致细胞严重损伤或死亡 (凋亡或坏死 ) .综述了钙稳态失调在外界因素引起细胞死亡中的作用、直接钙稳态失调的细胞死亡效应、以及钙离子在细胞凋亡中的作用 ,并讨论了上述作用的机制 。The concentration of calcium ion in cytoplasm is in strict control. Disequilibrium of calcium homeostasis will result in severe injury even death of cells. The roles of such disequilibrium in cells death resulted from exogenous factors, evidences of direct lethal effect of the disequilibrium on cell and effects of calcium ion in apoptosis were reviewedd. Mechanisms of these effects were discussed. In the end, on the basis of summary, a new way to inhibit cancer cell was suggested, by inducing disorder of calcium homeostasis selectively in cancer cells.

关 键 词：钙离子 钙稳态失衡 细胞凋亡 癌细胞抑制 

分 类 号：Q279[生物学—细胞生物学] R73－362[医药卫生—肿瘤]