二十二碳六烯酸抗心血管病作用的研究——Ⅱ.精制鱼油对大鼠血小板聚集功能的影响  

THE STUDIES ON EFFECT OF DOCOSAHEXAENOIC ACID UPON CARDIOVASCULAR DISEASE Ⅱ.THE INFLUENCE OF DHA AND EPA ENRICHED FISH OIL ON PLATELET AGGREGATION IN RATS

作　　者：王景梓[1] 周序斌[1] 张黎华[1] 吴葆杰[1] 

机构地区：[1]山东医科大学药理学教研室

出　　处：《山东医科大学学报》1991年第1期33-35,共3页Acta Academiae Medicinae Shandong

摘　　要：形成高胆固醇血症实验动物模型,观察含有高浓度二十二碳六烯酸的精制鱼油对血小板功能的影响。口服鱼油4周后,普通饲料组和高脂饲料组的血小板对花生四烯酸和胶原诱导的聚集均有明显减弱;对ADP诱导的血小板聚集,高脂组减弱明显,普饲组较少减弱。而我国北方居民常食用的花生油对普饲组和高脂组的血小板聚集均无明显影响。动物食用富含DHA的精制鱼油可减弱血小板对多种聚集诱导剂的反应。这对预防心血管病会产生有益的影响。DHA and EPA enriched fish oil(containing 47.1% DHA and 24.2% EPA)was administered by gastric intubation at the dose of 0.2ml/ (100g·day)for a period of 4 weeks to normal rats or hyperlipoproteinemia rats caused by high lipid and cholesterol feeding.The platelet aggregation was investigated.Compared with the control,the platelet aggregation were inhibited 36.5%,26.8% and 24.0% induced by AA,collagen and ADP separately on hyperlipoproteinemia rats,47.6%,23.8% and 13.0% on normal rats.The platelet aggregation was not significantly altered,both in normal or hyperlipoproteinemia rats which receved peanut oil commonly used by people in the north part of China.Results indicates oral DHA and EPA enriched fish oil inhibits platelet aggregation,it might have a benefit influence on cardiovascular disease.

关 键 词：鱼油 抗心血管病 血小板聚集 大鼠 

分 类 号：R972[医药卫生—药品]