血管内皮细胞生长因子在脑胶质瘤的表达  

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN HUMAN GLIOMAS

作　　者：王涛[1] 王越先[2] 杨培业[1] 

机构地区：[1]内蒙古医学院第一附属医院神经外科,内蒙古呼和浩特010050 [2]内蒙古医学院病理教研室

出　　处：《内蒙古医学院学报》2001年第4期216-219,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自治区自然科学基金项目 2 0 0 0 130 6

摘　　要：目的 :探讨血管内皮细胞生长因子 (VEGF)与胶质瘤发生、演进、诊断及预后的关系。方法 :采用免疫组化SP法研究 132例脑胶质瘤VEGF的表达。结果 :高分级胶质瘤VEGF呈高表达 ,而正常脑组织表达很低 (P<0 0 5 ) ,此规律在星形细胞瘤中更明显。髓母细胞瘤也呈高表达 (90 91% ) ,良恶性室管膜瘤、少突神经胶质瘤表达均略高 (P >0 0 5 )。结论 :VEGF在胶质瘤中的表达随病理分级的增高而增高 ,VEGF的表达对胶质瘤的发生、演化、诊断。Objective:To detect the VEGF expression in gliomas and the relationships between VEGF and the occurrence,progression,histological classification,grade,and diagnosis,prognosis of human gliomas.Methods:132 gliomas were detected by means of immunohistochemical S-P method.Results:VEGF expression was seen in 87 out of 132 gliomas(65.91%),in 1 of 9 NB(11.11%).The positive expression and quantitative analysis scores were 44.44% and 2.09±2.63,74.00% and 3.48±2.47,96.43% and 5.04±1.97 in BG,MG,HMG respectively.VEGF level in HMG were considerably higher than those in MG and BG(P<0 05).VEGF expression was observed in 10 out of 11 medulloblastomas(Meds).VEGF expression was found in cytoplasma of oligodendrogliomas.Conclusion:The VEGF expression level rises with the grade and plays an important role in the occurrence,transformation and progression of gliomas.

关 键 词：胶质瘤 血管内皮细胞生长因子 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]