替硝唑预防和治疗干槽症的临床观察  

Analgesic effects of tinidazole in the prevention and treatment of alveolalgia

作　　者：寿卫东[1] 叶炳飞[1] 邹昌宁[1] 

机构地区：[1]南京大学医学院附属口腔医院口腔颌面外科,江苏南京210008

出　　处：《医学研究生学报》2001年第6期513-515,共3页Journal of Medical Postgraduates

摘　　要：目的 :评价替硝唑预防和治疗干槽症的疗效及其安全性。　方法 :收集 1998年 12月至 2 0 0 0年 12月在我科防治的 12 0 0例患者 ,分别用替硝唑 (Tinidazole)预防智齿拔除术后干槽症 6 0 0例 (为试验组 )和甲硝唑 (Metron idazole)预防术后干槽症 6 0 0例 (为对照组 ) ;并用替硝唑治疗术后干槽症 14例 (为试验组 ) ;用甲硝唑治疗术后干槽症 14例 (为对照组 )。通过对临床疗效观察和实验室检查 ,以评价其疗效和安全性。对厌氧菌培养阳性的标本进行了替硝唑和甲硝唑的最小抑菌浓度测定。　结果 :替硝唑在防治干槽症的疗效明显优于甲硝唑 ,其不良反应也轻微。　结论 :替硝唑是一种高效、安全的抗厌氧菌新药 。Objectives:To evaluate the analgesic effects and safety of tinidazole in the prevention and treatment of alveolalgia. Methods:Tinidazole was used in 600 patients after the extraction of impacted tooth as the test group for the prevention of alveolalgia, and metronidazole was used in other 600 patients as the control group. The clinical and laboratory tests were carried out before and after the treatment. And the MIC of tinidazole and metronidazole were determined in samples of positive anaerobic cultures. Results:Twenty eight patients with alveolalgia were treated. It showed that it was significantly more effective in the test group than that in the control group. The MIC of the tinidazole group, however, was not different from that of the metronidazole group( P >0.05).There was also little side effects from the use of tinidazole. Conclusions:Tinidazole is an effective and safe antianaerobic medicine and can be used to replace metronidazole.

关 键 词：替硝唑 甲硝唑 干槽症 预防 治疗 

分 类 号：R782.31[医药卫生—口腔医学]