超临界萃取法提取川芎中有效成分的研究  

Studies on extraction of active ingredients from Ligusticum chuanxiong by supercritical fluid extraction

作　　者：张虹[1] 柳正良[2] 王洪泉[1] 

机构地区：[1]同济大学附属同济医院,上海200065 [2]第二军医大学药学院,上海200433

出　　处：《中草药》2001年第12期1077-1079,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的　考察影响超临界萃取川芎中有效成分的因素。方法　采用正交试验法 ,以超临界萃取为提取条件 ,以提取液中阿魏酸含量为考察指标 ,对影响阿魏酸提取工艺的因素进行了研究。结果　优选出川芎中阿魏酸的最佳超临界萃取条件。结论　提取阿魏酸的最佳 SFE条件是 :萃取罐的温度 70℃、萃取压力 35 MPa、CO2 流量2 5 kg/ h,萃取时间 2 .5 h。Object To study the conditions for the extraction of active ingredients in Ligusticum chuanxiong Hort by supercritical fluid extraction (SFE) Methods Conditions for the extraction were studied by orthogonal experimental design as guided by the content of ferulic acid presented in the extract Results The optimum conditions for the yield of ferulic acid were thus established Conclusion The best SFE conditions were: temperature of the extraction pot was 70 ℃ under the pressure of 35 MPa, CO 2 as the modifier with the flow rate of 25 kg/h, the time for extraction was 2 5 h

关 键 词：超临界萃取 阿魏酸 正交试验 川芎 

分 类 号：R284.2[医药卫生—中药学]