tk基因/GCV系统联合重组人肿瘤坏死因子-α衍生物治疗鼠脑胶质瘤  

Combined retrovirus-mediated tk gene/GCV system and derivative of recombinant human tumor necrosis factor-α therapy for rat glioma

作　　者：李涛[1] 李承晏[1] 李玲莉[2] 徐亚林[1] 曹剑锋[3] 封江南[3] 

机构地区：[1]武汉大学人民医院神经内科,430060 [2]武汉大学人民医院急诊科,430060 [3]武汉生物制品研究所免疫室

出　　处：《中华实验外科杂志》2001年第6期504-505,T001,共3页Chinese Journal of Experimental Surgery

摘　　要：目的　研究逆转录病毒介导的tk基因 /GCV系统联合重组人肿瘤坏死因子 α衍生物治疗鼠脑胶质瘤。方法　分别用tk基因 /GCV系统、重组人肿瘤坏死因子 α衍生物和两者联合进行治疗鼠脑胶质瘤 ,在治疗前、治疗后第 8、15、2 1天分别用核磁共振 (MRI)增强测量肿瘤大小 ,观察治疗后生存期。结果　联合tk基因 /GCV系统和重组人肿瘤坏死因子 α衍生物比单用其中一种的治疗效果好。结论　tk基因 /GCV系统联合重组人肿瘤坏死因子 α衍生物能提高鼠脑胶质瘤的治疗效果。Objective To investigate the effects of combinated retrovirus-mediated tkgene/GCV system and derivative of recombinant human tumor necrosis factor-therapy for rat glioma.Methods tk gene/GCV system, derivative of recombinant human tumor necrosis factor-α or both of them were used to treat glioma. The size of glioma was measured by MRI at the day before therapy, the 8th, 15th an d 21st day after therapy. The survival time of rats was observed after therapy.Results Glioma was more sensitive to combined tk gene/GCV system and derivative of recombinant human tumor necrosis factor-αthan either of them.Conclusion Combined tk gene/GCV system and derivative of recombinant human tumor necrosis factor-α could enhance the therapeutic effic acy.

关 键 词：TK基因 重组人肿瘤坏死因子-α衍生物 脑胶质瘤 基因治疗 GCV系统 

分 类 号：R739.41[医药卫生—肿瘤]