胃食管反流病的气道功能研究  

Studies on the Bronchial Functions in Gastroesophageal Reflux Disease

作　　者：陈宁[1] 冯惠强[1] 李慧[1] 饶梅冰[1] 

机构地区：[1]广东省第二中医院,广东广州510095

出　　处：《华夏医学》2001年第6期770-771,共2页Acta Medicinae Sinica

摘　　要：目的 :探讨胃食管反流病 (GERD)患者的气道反应性与痰液的变化。方法 :动态观察食管 p H和呼气流速峰值 (PEF) ,并作组胺激发试验和痰液检查。结果 :当食管 p H<5 .0时 ,1h后可见 PEF开始下降 ,并与 p H成正相关 (r=0 .97)。组胺激发试验有 40 .0 % (12 / 30 )出现阳性 ,但以轻度和最轻度为主。GERD患者的痰液量及其细胞总数与嗜酸性细胞数均高于正常对照组。结论Objective:To study the bronchial responsiveness and sputum production in gastroesophageal reflux disease(GERD).Methods:pH in esophagus and peak expiratory flow(PEF) were determined continually in 24h.Histamine inhalation provoking test and sputum examination were used in further study for airway functions.Results:When pH<5.0 in esophagus,PEF began to decrease in one hour,which showed possitive correlation with pH(r=0.97).Histamine inhalation provoking test exhibited PD 20 PEF value≤7 8μ mol in 40 0%(12/30)of patients with GERD.Amount of sputum,cell total and eosinophils in it were more than those of control.Conclusion:Gastroesophageal reflux can cause airway hyperresponsiveness,and copious sputa by inflammation and overscretion of mucus.

关 键 词：胃食管反流病 气道反应性 痰液分泌异常 支气管哮喘 

分 类 号：R571[医药卫生—消化系统]