中、晚期非小细胞肺癌144例用CAP、EP、IP三方案化疗疗效、毒性比较  

Comparison of Treatmental Results from CAP?EP and IP Regimens for Advanced

作　　者：潘明[1] 陈萍[1] 赵玉娟[1] 

机构地区：[1]四川省肿瘤医院,四川成都610041

出　　处：《华西医学》2001年第4期392-393,共2页West China Medical Journal

摘　　要：目的 :探讨中、晚期NSCLC较好的化疗方案。方法 :采取随机抽样调查方法将 1991年至 2 0 0 0年来采用CAP、EP、IP方案化疗的中、晚期NSCLC的治疗效果进行总结分析。结果 :CAP组CR +PR总缓解率 18 75 %(9/ 48) ,EP组 33 32 % (16 / 48) ,IP组 39 5 8% (19/ 48) ,X2 检验IP组与CAP组之间疗效有显著性差异P <0 0 5 ,而EP组与IP组之间无显著性差异P >0 0 5 ,CAP组与EP组之间无显著性差异。毒副作用骨髓抑制 (Ⅲ°+Ⅳ°)CAP组 45 38% ,EP组 6 2 5 % ,IP5 6 2 5 % ,消化道反应各组无显著性差异。结论 :治疗非小细胞肺癌IP方案优于CAP方案。Objective:TO research a favorable chemotherapy regimen for advanced non-small cell lung cancers(NSCLC).Methods:From 1991 to 2000,the curative effect of CAP?EP and IP regimens for advanced NSCLS were analyzed through randomized spot check.Results:The overall response rates(CR+PR)were 18 75%(9/48),33 33%(16/48)and 39 58%(19/48)respectively in CAP?EP and IP group with statistical significance between IP and CAP group( P <0 05).No statistical significance was seen in the treatment result between EP and IP group( P >0 05).The side effect included myelosuppression(Ⅲ°and Ⅳ°)in CAP.Ep and IP regimens having 45 8%,62 5% and 56 25%,respectivelyo.There was no significant difference in gastrointestinal side effects among all of the three groups.Conclusion:The curative result of IP regimen for NSCLC was superior to that of CAP regimen.

关 键 词：非小细胞肺癌 NSCLC 化学疗法 疗效 毒性 肺肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]