高热对大鼠局部脑缺血再灌流损伤的影响  

Effects of hyperthermia on cerebral ischemia-reperfusion injury in rats

作　　者：杨世方[1] 凌亦凌[1] 于占久[2] 申玉学[2] 夏晓红[2] 董力[2] 孟爱宏[1] 

机构地区：[1]河北医科大学病理生理教研室,河北石家庄050017 [2]河北省医学科学院病理生理教研室,河北石家庄050021

出　　处：《中风与神经疾病杂志》2001年第6期329-331,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的 研究短暂高热（脑温４０℃）在脑缺血再灌流不同时间对脑损伤的影响。方法 采用自制的大鼠脑温调控装置，分别于大鼠局部脑缺血１ｈ、再灌流２ｈ、２４ｈ、４８ｈ。对大鼠进行短暂的高热或常温处理，高热或常温处理后２４ｈ对大鼠进行神经功能缺损评分，７２ｈ后测脑梗死体积。结果 大鼠脑缺血再灌流２ｈ时，４０℃高热可导致脑梗死体积显著增大，神经功能显著恶化。而再灌流２４ｈ或４８ｈ后高热对脑损伤的作用不明显。结论 脑缺血后，短暂高热仅在再灌流早期对缺血性脑损伤有加重作用，高热加重缺血性脑损伤的时间窗可能仅限于脑缺血再灌流后２４ｈ内。Objective To investigate the effects of hyperthermia on ischemic brain injury in rats subjected to transient focal cerebral ischemia followed by a various period of reperfusion. Methods Rats were subjected for 3h of hyperthermia (40℃) or normothermia (37℃) after 1h of focal cerebral ischemia followed by 2h、 24h、 48h of reperfusion, respectively, by using a self-made brain temperature-regulating apparatus for rat. The neurologic dis- ability scores were evaluated at 24h after temperature modulation and the brain infarct volume measured 72h after temperature modulation. Results The hyperthermia imposed 2h after reperfusion might significantly increase the brain infarct volume and worsen the neurologic disabilitv, whereas the effects of hyperthermia imposed more than that at 24h after reperfusion on the brain injury were not obvious. Conclusions The brief hyperthermia imposed only at the early time of reperfusion could exacerbate brain injury, the time window for aggravation of ischemic in- jury by delayed hyperthermia appers to be less than 24h after reperfusion.

关 键 词：脑缺血 再灌注损伤 脑损伤 高热 动物实验 

分 类 号：R743.31[医药卫生—神经病学与精神病学]