胃癌患者及其手术前后红细胞免疫功能与淋巴细胞功能之间的相关性研究  

Relationship Between Erythrocyte Immune Function and Lymphocyte Cell Function in Patients with Gastric Carcinoma before and after Operation

作　　者：李勇[1] 赵群[1] 刘冀红[1] 焦志凯[1] 张志栋[1] 于跃明[1] 范立侨[1] 马志学[1] 刘品一[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《中国中西医结合外科杂志》2001年第6期370-372,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：河北省科委资助项目 (No.972 76 16 0D)

摘　　要：目的 :探讨胃癌患者及其手术前后红细胞免疫功能的变化及与淋巴细胞免疫功能之间的相关性。 方法 :72例胃癌患者 ,2 0例正常人为对照 ,检测血红细胞C3 b受体花环 (RBC -C3 bRR)和免疫复合物花环 (RBC -ICR) ,T淋巴细胞亚群、B细胞含量 ;NK细胞活性、血清循环免疫复合物 (CIC)、血清免疫球蛋白和补体。 结果 :(1)胃癌患者RBC -C3 bRR显著降低 ,RBC -ICR显著升高 (P <0 0 1)。 (2 )术后组RBC -C3 bRR显著升高 ,RBC -ICR显著降低 (P <0 0 1)。 (3)胃癌患者CD3+、CD4+、CD4+ CD8+,NK细胞活性 ,B细胞 ,IgG、IgA均显著降低 ,CIC显著升高 (P <0 0 5或P <0 0 1) ;手术后CD3+、CD4+、CD4+ CD8+、NK细胞活性 ,免疫球蛋白IgA均有显著提高 (P <0 0 1) ;胃癌患者术前组及手术前后RBC -C3 bRR变化组与CD3+、CD4+、NK细胞组均呈显著正相关 (P <0 0 1)。 结论 :(1)胃癌患者红细胞免疫粘附功能、淋巴细胞免疫功能低下。 (2 )手术可使胃癌患者红细胞免疫、淋巴细胞免疫功能明显改善。 (3)红细胞免疫粘附功能与T淋巴细胞、NK细胞活性之间关系密切。To investigate the changes and their relationship between erythrocyte immune function and lymphocyte function in patients with gastric carcinoma and the influence of operation Methods:In 72 cases of gastric carcionoma and in 20 healthy people as control,the red blood cell C 3b receptor rosette(RBC-C 3bRR),immune complex resette(RBC-ICR),T lymphocyte subsets,B cell,natural killer cell activity,circulating immune complex,immunoglobulin and complement in serum were detected.Results:(1)the RBC-C 3bRR were significantly lower in the gastric carcinoma group ( P <0 01)and RBC-ICR were elevated( P< 0 01).(2)The RBC-C 3bRR significantly increased in the postoperative group( P <0 01),and the RBC-ICR were significantly lower in the postoperative group( P <0.01).(3)The CD 3 +,CD 4 +,CD 4 +/CD 8 +,B cell and natural killer cell activity,IgG,IgA were signifcanlty lower and CIC markedly increased in patients with gastric carcinoma ( P<0 05 or P <0.01).After operation the CD 3 +,CD 4 +,CD 4 +/CD 8 +, natural killer cell activity and IgA increased much higher than in the preoperative group( P <0 01).A positive correlation between RBC-C 3bRR and CD 3 +,CD 4 +,natural killer cell activity were noted in the preoperative group and the changes before and after operation( P <0.01).Conclusion:(1)The erythrocyte immune function and lymphocyte cell function obviously lower in patients with carcinoma.(2)The erythrocyte immune function and lymphocyte cell function can be improved after recieving operation.(3)There is a close relationship between erythrocyte immune function and T lymphocyte subsetes and natural killer cell activity.

关 键 词：胃癌 红细胞免疫 T淋巴细胞亚群 NK细胞 体液免疫 

分 类 号：R735.2[医药卫生—肿瘤]