MTS_1/p16和MTS_2/p15基因共丢失与原发性非小细胞肺癌预后的研究  

STUDY ON THE RELATIONSHIP BETWEEN CODELETIONOF BOTY p16/p15 GENES AND PROGNOSIS OF PATIENTSWITH NON-SMALL CELL LUNG CANCER

作　　者：胡颖[1] 周 瑾[1] 许凯黎[1] 廖美琳[2] 丁嘉安[3] 

机构地区：[1]上海市肿瘤研究所,上海200032 [2]上海市胸科医院 [3]上海市肺科医院

出　　处：《肿瘤》2001年第6期443-445,共3页Tumor

基　　金：本课题受上海市领先学科基金资助(984119002)

摘　　要：目的 探讨p15/p16基因纯合性共丢失与原发性非小细胞癌(NSCLC)患者预后的相关性。方法 采用聚合酶链式反应(PCR)技术,先后检测140例NSCLC手术标本中p15/pl6双基因的共丢失。结果 肺腺癌组织中p15/pl6基因共丢失率明显高于肺鳞癌(P＜0.05),而双丢失组的患者生存率与患者的性别、年龄及TNM分期等因素无关(P＞0.05)。p15/pl6基因共丢失组的患者生存率明显低于未丢失组,两组之间呈著性差异(P＜0.01)。经统计学处理提示TNM分期对患者累计生存率的影响也具有明显差异(P＜0.05)。结论 据于p15/pl6基因共丢失率与肺癌患者生存期密切相关,因此检测pl5/pl6基因共丢失可作为NSCLC患者预后判断的指标。ve To study the relationship between thecodeletion of both p15/P16 genes and the prognosis of patients withnon-small cell lung cancer. Methods The loss of homozygosity onp15 and pl6 genes was examined by polymerase chain reaction(PCR) in 140 cases with non-small cell lung cancer. Results Thecodeletion rate of pl5 and pl6 in adenocarcinoma was significantlyhigher than that in squamous carcinoma (P<0.05), while it wasnot related to sex, age and TNM stages(P>0.05) .The survival ratein NSCLC patients with codeletion of pl5 and pl6 genes wassignificantly lower than that in patients without codeletion of bothgenes(P<0.01).Conclusion According to the relationshipbetween the codeletion of both pl5 and pl6 genes and the survival ofNSCLC patients, detecting codeletion of both p15 and pl6 genes canbe used as a predictive marker for prognosis of the patients withNSCLC.

关 键 词：非小细胞肺癌 p15/p16基因共丢失 预后 MTS 肺肿瘤 

分 类 号：R73－34[医药卫生—肿瘤] R734.2[医药卫生—临床医学]