褪黑激素对胃黏膜的保护作用及其机制  

Protection of melatonin to gastric mucosa and its possible mechanism

作　　者：王化虹[1] 陈宝雯[1] 曹之宪[2] 

机构地区：[1]北京大学第一医院消化内科,100034 [2]香港大学药理系

出　　处：《中华消化杂志》2001年第8期477-480,共4页Chinese Journal of Digestion

摘　　要：目的　探讨褪黑激素和血清素对鼠胃酒精性溃疡形成及黏膜血流的影响。方法　制备胃在体动物模型。分别皮下注入血清素及同容积生理盐水。用褪黑激素及同容积蒸馏水作为浸育液分别放入各组鼠的胃腔中。 30min末测毕胃黏膜血流后 ,采用 40 %的酒精作为浸育液分别放入各组鼠胃腔中 ,继续检测胃黏膜血流并测量胃黏膜损伤指数。结果　褪黑激素和血清素两者均不能损伤鼠胃黏膜 ,但血清素可降低胃黏膜血流 ,且与其剂量相关。褪黑激素可减轻由酒精引起的胃黏膜损伤和胃黏膜血流减少 ,而血清素可加重酒精引起的胃黏膜损伤和胃黏膜血流减少 ,但可被褪黑激素部分逆转。结论　胃黏膜的损伤与胃黏膜血流有关 ,但不是溃疡形成的唯一因素。因此 。Objective Effects of melatonin and serotonin on ethanol induced ulceration in the rat stomach were investigated. Methods Serotonin was injected subcutaneously, then melatonin solution and finally ethanol was put into the ex vivo gastric lumen to prepare the experimental models. Glandular mucosal blood flow (GMBF) and the gastric mucosal injury were observed. Results Melatonin and serotonin administration did not induce observable gastric mucosal of damage in the ex vivo stomach, but the serotonin reduced glandular mucosal blood flow (GMBF) with dose dependence in this organ. Ethanol reduced GMBF and induced visible glandular mucosal damage. The latter effect was prevented by melatonin pretreatment. Serotonin pretreatment aggravated the gastric mucosal injury and GMBF changes induced by ethanol, but these effects were partially reversed by melatonin. Conclusion The findings indicate that the GMBF and gastric injury are related, the reduction in GMBF, however, may not be the sole factor responsible for ulceration. The antagonistic effects of melatonin on serotonin action on the stomach suggest that melatonin may play a modulator role for serotonin action on the gastrointestinal tract.

关 键 词：褪黑激素 血清素 溃疡形成 胃黏膜 保护作用 动物实验 

分 类 号：R573[医药卫生—消化系统]