胃癌组织中过氧化物酶体增殖因子活化受体γ和维甲酸受体α的表达及意义  

Expression and significance of PPARγ and RXRα in gastric carcinoma

作　　者：幺立萍[1] 吴开春[1] 吴汉平[1] 宋宝华[1] 乔泰东[1] 樊代明[1] 

机构地区：[1]第四军医大学西京医院消化疾病研究所,西安710032

出　　处：《中华消化杂志》2001年第7期393-396,共4页Chinese Journal of Digestion

基　　金：国家自然科学基金资助项目 (3 9870 3 2 0 )

摘　　要：目的　研究过氧化物酶体增殖因子活化受体γ(PPARγ)和维甲酸受体α(RXRα)在慢性胃炎、胃黏膜不典型增生及胃癌组织中的表达 ,探讨PPARγ和RXRα在该演进序列中的意义及相关性。方法　采用ABC免疫组化法 ,检测 5 3例胃癌手术标本中PPARγ和RXRα的表达 ,同时随机选取 18例胃黏膜不典型增生、31例慢性非萎缩性胃炎及 30例慢性萎缩性胃炎作对照研究。结果　PPARγ和RXRα于胃癌中的表达率为 41.5 %和 5 4.7% ,在胃黏膜不典型增生为 2 7.8%和 38.9% ,慢性萎缩性胃炎中为 10 .0 %和 2 0 .0 % ,慢性非萎缩性胃炎中为 6 .5 %和 16 .1% ;从慢性胃炎、胃黏膜不典型增生到胃癌 ,PPARγ和RXRα阳性率呈递增趋势 ;与慢性胃炎相比 ,胃黏膜不典型增生及胃癌中PPARγ和RXRα的表达率均显著升高 (P <0 .0 5 ,P <0 .0 1) ;PPARγ和RXRα表达与胃癌有无淋巴结转移及胃癌的分化程度无相关性 (P >0 .0 5 ) ;胃癌中PPARγ和RXRα的表达呈显著正相关 (r =0 .5 4)。结论　PPARγ和RXRα于胃癌及胃癌前病变中表达上调 ,可能是胃癌发生过程中的早期事件。Objective To investigate the significance of expression of peroxisome proliferator activated receptor γ(PPARγ) and retinoid X receptor α(RXRα) in chronic gastritis, gastric mucosal dysplasia and gastric carcinoma and to identify the correlation between PPARγ and RXRα. Methods Avidin biotin peroxidase complex immunohistochemical methods were adopted to examine the expression of PPARγ and RXRα in 53 patients with gastric carcinoma, and 18 with gastric mucosal dysplasia, 31 with chronic non atrophic gastritis and 30 with chronic atrophic gastritis were served as controls. Results The positive rates of PPARγ and RXRα were 41.5% and 54.7% in gastric carcinoma respectively, 27.8% and 38.9% in gastric mucosal dysplasia, 10.0% and 20.0% in chronic atrophic gastritis, 6.5% and 16.1% in chronic non atrophic gastritis. From chronic non atrophic gastritis, chronic atrophic gastritis to gastric carcinoma, expressions of PPARγ and RXRα showed an ascending tendency. Compared with those in chronic gastritis, expressions of PPARγ and RXRα in gastric mucosal dysplasia and gastric carcinoma were significantly enhanced ( P<0.05, P<0.01 ). In gastric carcinoma, expressions of both PPARγ and RXRα were not relative with tumor cell differentiation and metastasis of lymph nodes ( P >0.05). There was a significant correlation between expressions of PPARγ and RXRα in gastric carcinoma ( r =0.54). Conclusion PPARγ and RXRα protein overexpression is a relatively early event in gastric carcinogenesis, and it may play both an independent and synergetic role in progression of gastric carcionma.

关 键 词：过氧化物酶体增殖因子活化受体Γ 维甲酸α 胃癌 胃黏膜不典型增生 慢性胃炎 

分 类 号：R735.2[医药卫生—肿瘤]