前列地尔治疗急性脑梗死  

Alprostadil for acute cerebral infarction

作　　者：解旭东[1] 冀风云[1] 王婷[1] 刘建辉[1] 王健[1] 姚斌[1] 

机构地区：[1]中国人民解放军252医院神经内科,河北保定071000

出　　处：《中国新药与临床杂志》2002年第2期71-73,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察前列地尔注射液 (前列地尔脂微球载体靶向制剂 )治疗急性脑梗死的疗效。方法 :急性脑梗死病人共 98例 ,分为前列地尔组 5 2例 ,年龄6 4a±s 9a(45～ 70a) ,对照组 4 6例 ,年龄 6 5a±11a(49～ 72a)。前列地尔组予前列地尔 10 μg +氯化钠注射液 10mL ,iv ,qd ,氯化钠注射液 2 5 0mL +三七总皂苷 0 .6 g ,iv ,gtt ,qd ,另予常规治疗 (甘露醇、吡拉西坦、胞磷胆碱、三磷腺苷、辅酶A、尼莫地平等 ) ,疗程 2wk。对照组不予前列地尔外 ,其余治疗同前列地尔组 ,治疗 2wk。结果 :前列地尔组总有效率 94 % ,对照组 89% (P <0 .0 5 )。前列地尔组与对照组前后血液流变学指标均有显著改善 (均P<0 .0 1)。结论AIM: To observe the efficacy of alprostadil (Lipo prostaglandin E 1) in treating acute cerebral infarction. METHODS: Ninety eight patients with acute cerebral infarction were divided into two groups. Alprostadil group of 52 patients (M 30, F 22; age 64 a± s 9 a) received alprostadil 10 μg in sodium chloride injection 10 mL, iv, qd, and panax notoginseng saponins 0.6 g in sodium chloride injection 250 mL iv, gtt, qd, and conventional therapy (mannitol, piracetam, citicoline, ATP, coenzyme A, nimodipine, etc.) for 2 wk. Other 46 patients of the control group (M 27, F 19; age 65 a±11 a) only received panax notogmseng saponins 0.6 g in 5% glucose injection 250 mL or sodium chloride injection 250 mL iv.gtt,qd, and conventional therapy for 2 wk. RESULTS: The total effective rate in the alprostadil group (94%) was higher than that in the control group (89%, P <0.05). Changes of all hemorheological characters were very significant in two groups ( P <0.01). CONCLUSION: alprostadil (lipo prostagland in E 1) is a valuable drug in treating acute cerebral infarction.

关 键 词：前列地尔 脂质体 微球体 脑梗死 治疗 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]