丁咯地尔与尼莫地平治疗血管性痴呆的双盲对照研究  

Buflomedil vs nimodipine in treating vascular dementia: a double-blind comparative study

作　　者：刘赛男[1] 李义召[1] 韩丹春[1] 迟兆富[1] 张锐 王宁庭 赵富华 朱屹东 

机构地区：[1]山东医科大学附属医院 [2]齐鲁制药厂药物研究所,山东济南250001

出　　处：《中国新药与临床杂志》2002年第2期74-76,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较丁咯地尔与尼莫地平治疗血管性痴呆的临床疗效。方法 :70例血管性痴呆病人 ,以双盲随机对照研究方法分为尼莫地平组 35例 ,丁咯地尔组 35例。分别给尼莫地平 30mg ,丁咯地尔15 0mg ,po ,tid ,8wk为一个疗程。治疗后评价MMSE ,HDS ,ADL ,WMS ,CGI ,EI及不良反应。结果 :治疗后WMS ,MMSE ,ADL ,CGI ,EI评分尼莫地平组为 (5 9± 2 2 ,2 0± 6 ,30± 12 ,3.0± 0 .7,1.9±0 .7)分 ;丁咯地尔组为 (70± 18,2 2± 4 ,2 6± 9,2 .2±0 .9,2 .5± 0 .8)分 ,2组比较P <0 .0 5或P <0 .0 1,2组不良反应比较P >0 .0 5。结论AIM: To compare the efficacies of buflomedil and nimodipine in the treatment of vascular dementia. METHODS: Using double blind radomized comparative method, 70 patients with vascular dementia were randomly divided into two groups. The nimodipine group of 35 patients (M 18, F 17; age 62 a± s 12 a) was teated with nimodipine 30 mg, po, tid for 8 wk. The buflomedil group of 35 patients (M 20, F 15; age 64 a±7 a) was treated with buflomedil 150 mg, po, tid for 8 wk. Then their MMSE, HDS, ADL, WMS, CGI, EI and adverse reaction were compared. RESULTS: In nimodipine group the scores of WMS, MMSE, ADL, CGI, EI were 59±22, 20±6, 30±12, 3.0±0.7, 1.9±0.7, as that were 70±18, 22±4, 26±9, 2.2± 0.9 , 2.5±0.8 in buflomedil group. There were significant differences between the two groups ( P <0.05, P <0.01). The rates of adverse reaction were equal. CONCLUSION: With equal safety, buflomedil is more effect than nimodipine in treating vascular dementia.

关 键 词：丁咯地尔 尼莫地平 片剂 血管性痴呆 双盲法 治疗 

分 类 号：R749.105[医药卫生—神经病学与精神病学]