脑梗死患者血清一氧化氮及高密度脂蛋白胆固醇含量测定的意义  

Significance of measuring the concentrations of the nitric oxide(NO) and high density liporotein (HDL-c) of sear in the patients of brain infarction

作　　者：邹爱民[1] 张盈华[1] 张利朝[1] 殷缨[1] 陶秦渝[1] 

机构地区：[1]第四军医大学唐都医院中心实验室,西安710038

出　　处：《中国急救医学》2001年第12期697-698,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨一氧化氮 (NO)、一氧化氮合成酶 (NOS)和高密度脂蛋白胆固醇 (HDL -c)在脑梗死患者发病过程中的含量变化及其意义。方法　检测 5 3例脑梗死急性期患者和 40例健康对照组血清中的NO、NOS和HDL -c的含量 ,并进行显著性检验和相关性分析。结果　与对照组比较 ,脑梗死患者NO和NOS含量显著高于对照组 (P <0 0 1,P <0 0 5 ) ,其中皮层动脉梗死组高于腔隙性梗死组 (P <0 0 1,P <0 0 5 )。而脑梗死组HDL -c显著低于对照组 ,其中皮层动脉梗死组低于腔隙性梗死组 (P <0 0 1) ,NO与HDL -c呈现负相关关系 (r =- 0 5 5 6 ,P <0 0 1)。结论　脑梗死患者体内自由基反应及HDL -c合成失去平衡 ,观察NO、NOS及HDL -c值的变化具有重要意义。Objective To study the significance and correlation between the nitric oxide (NO)?nitric oxide synthesis (NOS) and high-density liporotein(HDL-c) in the patients of brain infarction.Methods The values of NO and NOS high-density liporotein of sera in the group of 53 patients suffer from the brain infarction and the control healthy group of 40 patients were detected.Results The determination values of NO?NOS in brain infarction patients was higher than those in the control group( P <0 01 and P <0 05).The values of NO and NOS in the group of cortex artery infarction were higher than those in the group of lacuna infarction ( P <0 01 and P <0 05).However the determination value of HDL-c in brain infarction patients was lower than those in the control group. The values of HDL-c in the group of cortex artery infarction were lower than those in the group of lacuna infarction ( P <0 01). Moreover NO and HDL-c were correlated negatively in the brain infarction (r=-0 556, P <0 01).Conclusion The values of NO?NOS and HDL-c were not balance in the vary stages of brain infaction.It' s important to observe the changes of values of NO?NOS?HDL-c.

关 键 词：一氧化氮 NO 一氧化氮合成酶 高密度脂蛋白胆固醇 HDL-C NOS 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]