对苯二甲酸、乙二醇、联苯-联苯醚联合作用对肝脏损伤的实验研究  

Study on the injury of liver induced by terephthalic acid ethylene glycol and/or dowtherm A in rats

作　　者：姚宏伟[1] 王心如[2] 徐锡坤[2] 施爱民[1] 杨正南[1] 李泽林[1] 王顶贤[1] 

机构地区：[1]南京医科大学第三附属医院,南京211900 [2]南京医科大学公共卫生学院

出　　处：《卫生研究》2002年第1期12-14,共3页Journal of Hygiene Research

基　　金：卫生部科研基金 (No .3 - 92 - 1 0 9);江苏省科技厅自然科学基金 (No.92 0 33)

摘　　要：为研究对苯二甲酸 (TPA)、乙二醇 (EG)、联苯 联苯醚 (DOW)对大鼠肝脏损伤的联合作用及其损伤机制 ,采用亚慢性动物实验 ,利用三因素两水平析因设计方法 ,分析研究了反映大鼠肝脏损伤的酶学、生化和形态学指标。结果表明 ,TPA、EG、DOW各联合染毒组大鼠的血清ALT活性和血清总胆汁酸 (TBA)含量 ,与单剂量染毒组及对照组相比均有不同程度的增高 ,析因分析结果提示 ,此 3种物质对肝脏损伤的联合作用特征表现为相加 (TPA +EG)、协同 (EG +DOW)、协同 (TPA +DOW)和相加作用 (TPA +EG +DOW) ,并通过形态学观察进一步得到验证。The joint injury actions and mechanisms of terephthalic acid (TPA), ethylene glycol (EG) and/or dowtherm A (DOW) on liver in rats were investigated. A subchronic toxicity study was designed by a 2(3) factorial method. Some enzymes, biochemical and morphologic indices reflecting the injury of liver were studied. The results showed that serum ALT and serum total bile acid (TBA) of rats in the combined intoxication groups were significantly higher than those in the groups with single toxic agent and control group. The results of factorial analysis showed that the joint action induced by TPA, EG and/or DOW were characterized as additive (TPA+EG), synergistic (EG+DOW), synergistic (TPA+DOW) and additive(TPA+EG+DOW)actions. The deduction was identified by morphologic observations.

关 键 词：对苯二甲酸 乙二醇 联苯-联苯醚 联合作用 肝损伤 实验研究 职业危害 

分 类 号：R575[医药卫生—消化系统] R135.1[医药卫生—内科学]