爱康宁胶囊体外抗癌作用及毒性实验  

Cancer-fighting Activity in Vitro and Toxicity of Aikangning Capsules

作　　者：郑敏[1] 杨静[2] 陈业文[1] 李立中[1] 

机构地区：[1]咸宁医学院药理学教研室,湖北咸宁437100 [2]武汉大学医学院药理学教研室,湖北武汉430071

出　　处：《咸宁医学院学报》2001年第4期248-250,共3页Journal of Xianning Medical College

摘　　要：目的观察爱康宁胶囊体外抗肿瘤活性及毒副作用。方法采用双层琼脂集落形成实验观察爱康宁胶囊的体外抗癌作用 ,并作急性毒性限量实验观察爱康宁胶囊的毒性作用。结果爱康宁胶囊对人癌细胞 (肝癌BEL -74 0 2、胃腺癌MGC -80 -3和食管癌Eca1 0 9)有明显的细胞毒作用。小鼠腹腔注射LD50 为 39.8± 4 .5 g/kg ,急性毒性限量试验小鼠口服 6 0 0 g/kg·d ,连用 7d ,无明显毒性。 结论爱康宁胶囊可通过直接杀灭癌细胞而发挥显著的抗肿瘤作用 ;对机体毒性小。Objective To study the cancer-fighting activity in vitro and toxicity of Aikangning Capsules.Methods The cancer-fighting activity were observed by agar plate method and the toxcity by acute maximal tolerance dose toxicity testing.Results Studies in vitro found Aikangning could produce obvious cytotoxicity on BEL-7402 human hepatocellular carcinoma cell,MGC-80-3 human gastric adenocarinoma cell and Eca109 human esophageal carcinoma cell.LD50 of Aikangning on mice for intraperitoneal administration was 39.8±4.5g/kg.The acute maximal tolerance dose toxicity testing found that Aikangning (600mg/kg·d po ×7) didn’t show obvious toxicity on mice.Conclusion Aikangning Capsules could produce obvious cancer-fighting effects by killing cancerous cell directly,showing less toxicity.

关 键 词：爱康宁胶囊 毒性试验 肿瘤治疗 体外抗癌作用 

分 类 号：R73－361[医药卫生—肿瘤] R979.1[医药卫生—临床医学]