消瘀片及其组分对粥样硬化兔ET-1体内和NO影响比较研究  

Comparison of Effects of Xiaoyu Tablets and its Constituents on Endothelin-1 and Nitric Oxide in Atherosclerotic Rabbits

作　　者：谢梅林[1] 顾振纶[1] 朱路佳[1] 陆群[1] 

机构地区：[1]苏州中药研究所,苏州215007

出　　处：《中成药》2001年第9期664-666,共3页Chinese Traditional Patent Medicine

基　　金：香港保健协会资助项目 ( 96 0 0 86 )

摘　　要：目的 :探讨消瘀片处方的合理性。方法 :采用动脉粥样硬化兔模型 ,观察消瘀片及其组分对体内ET 1和NO含量的影响。结果 :消瘀片对降低血浆和血管壁组织中ET 1含量 ,增加血清和血管壁组织中NO含量均较其相应组分的丹参水提物或山楂醇提物更明显。结论 :丹参水提物和山楂醇提物合用后 ,对降低粥样硬化兔体内ET 1和增加NO含量具有明显的协同作用。Objective: To determine the rationality of prescription of Xiaoyu tablets. Methods: The effects of Xiaoyu tablets and its single constituents on endothelin-1(ET-1) and nitric oxide(NO) in atherosclerotic rabbits were observed. Results: Xiaoyu tablets showed stronger actions than its single constituents (extract of radix salviae miltiorrhizae or fructus crataegi) in decreasing the contents of ET-1 in plasma and atherosclerotic vessel wall and increasing the contents of NO in serum and atherosclerotic vessel wall. Conclusion: There was the obvious synergism on reduction of ET-1 and elevation of NO in atheroscleerotic rabbits when both extracts of the Chinese herbal medicines were simultaneously used.

关 键 词：消瘀片 丹参 山楂 内皮素-1 一氧化氮 动脉粥样硬化 

分 类 号：R285.6[医药卫生—中药学]