巨大脑胶质瘤的分次伽玛刀治疗  

Fractionated Gamma Knife Radiosurgery for Giant Gliomas

作　　者：赵洪洋[1] 李美华[2] 王骏业[3] 林宁[1] 林敏华[1] 张方成[1] 朱贤立[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院γ刀中心,武汉430022 [2]江西医学院第一附属医院神经外科,南昌330006 [3]湖北省肿瘤医院,武汉430070

出　　处：《中国临床神经外科杂志》2002年第1期5-7,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的 探讨巨大脑胶质瘤的分次γ刀治疗及其疗效。方法 巨大脑胶质瘤的γ刀治疗分两次或三次完成,每次间隔1d,分次照射的周边剂量为5～10 Gy。治疗效果通过MRI和临床表现综合评估。结果 随访3～33月,28例巨大脑胶质瘤分次γ刀治疗有效率为78.6％,2例病人γ刀术后出现迟发性脑水肿。治疗效果与肿瘤分化程度有关,而与肿瘤大小无关。结论 巨大脑胶质瘤分次γ刀治疗效果显著,但其远期疗效有待进一步的临床和实验观察。Objective To explore the treatment of giant gliomas with fractionated gamma knife surgery. Methods The two or three courses of low-dose treatment were planned for fractionated gamma knife surgery in 3 or 5 days with the marginal dose of 5~10Gy in each radiation session. The therapeutic results were evaluated on the MRI findings and clinical manifestations of these patients. Results After a follow-up of 3-33 months, the growth-controlled rate of 28 gliomas treated with fractionated gamma knife surgery was 78.6%, 2 cases showed delayed brain edema after the radiosurgery. The outcome of treatment was related to the extent of differentiation of the tumors and the times of the fractionated treatment, but not to the size of tumors. Conclusion The fractionated gamma knife surgery for giant gliomas is practicable, but further study and long-term follow-up are necessary to develop the fractionated gamma knife radiosurgery as a safe and effective therapeutic method for the malignant gliomas.

关 键 词：脑胶质瘤 疗效 伽玛刀治疗 脑肿瘤 

分 类 号：R739.410.5[医药卫生—肿瘤]