动脉介入化疗加手术治疗四肢软组织肿瘤  

Intraarterial Chemotherapy Plus Surgery in Patients with Extremity Soft Tissue Sarcoma

作　　者：傅红[1] 师英强[1] 莫善兢[1] 朱慰祺[1] 周旭根[1] 周烨[1] 

机构地区：[1]复旦大学附属肿瘤医院外科,上海200032

出　　处：《复旦学报（医学版）》2002年第1期69-70,共2页Fudan University Journal of Medical Sciences

摘　　要：目的　探讨动脉介入化疗加手术治疗四肢软组织肿瘤的方法与临床价值。方法　 18例肢体软组织肿瘤 ,其中 11例 ( 61% )术前影像学检查显示肿瘤与大血管及神经粘连侵犯。分别采用股动脉或肱动脉插管 ,介入化疗 2至 3周后 ,施行肿瘤广泛切除并保存患肢功能。结果　动脉介入后病理学检查 ,肿瘤均有不同程度坏死 ,体积缩小 ,周围水肿浸润带明显减少 ,肿瘤与邻近组织尤其大血管及神经间隙增宽 ,术中得以分离切除并保存患肢 ,术后随访 10～ 5 2个月 ,患肢基本功能正常。结论　对四肢软组织肿瘤 ,影像学检查大血管与神经受累但有保肢可能者 ,术前动脉介入化疗对提高切除率、降低局部复发与远处转移特别是保存患肢与功能起到积极作用。Purpose: To evaluate the clinical therapeutic results of intraarterial chemotherapy plus surgery on patients with extremity soft tissue sarcoma. Methods: From 1997 to 2000, 18 patients with extremity soft tissue sarcoma were treated with intraarterial chemotherapy preoperatively plus surgery two weeks later. Of them, 11 cases (61%) were confirmed to be adherent to the major vessels and nerves nearby by ultrasonics and CT scan. After the treatment, the limb-preserving resction was achieved successfully, which does not substantially interfere with the function of the extremity. Results: The size of tumor on all patients decreased gradually with a remarkable necrosis of the cells and the less invasive edge between tumor, vessel and nerve was obtained, which led to a sound limb-preserving resction with their function. Conclusions: The use of intraarterial chemotherapy plus surgery is an ideal approach upon extremity soft tissue sarcoma patients for limb-preserving resection.

关 键 词：四肢软组织肿瘤 动脉介入化疗 保肢手术 

分 类 号：R739.96[医药卫生—肿瘤] R738.6[医药卫生—临床医学]