白血病心脏浸润所致心肌凋亡研究  

Myocardial cell apoptosis caused by leukemic cell infiltration of rat heart

作　　者：贾晋松[1] 哈森[1] 苏秀兰[2] 孟庆余[1] 

机构地区：[1]内蒙古医学院第一附属医院内科,内蒙古呼和浩特010050 [2]内蒙古医学院基础部细胞化学教研室,内蒙古呼和浩特010050

出　　处：《心脏杂志》2001年第6期459-460,共2页Chinese Heart Journal

摘　　要：目的 :研究白血病细胞心脏浸润时心肌细胞的凋亡情况。方法 :建立小鼠白血病模型 ( L6 1 5) ,采用流式细胞术( FCM)检测小鼠心肌细胞的细胞周期和细胞凋亡率。结果 :白血病组小鼠的心肌凋亡率明显高于正常对照组 ( P<0 .0 1)。结论 :白血病细胞心脏浸润可使心肌细胞凋亡率增高。AIM:To investigate myocardial cells apoptosis when leukemic cell infiltrate heart. METHODS:Establishment of leukemia models(L 615 ) in rat;detection of apoptotic rate of myocytes and cellular cycle by flow cytometry. RESULTS:Apoptotic rates of myocytes in two leukemia groups were significantly higher than that in control group ( P <0.01). CONCLUSION:Apoptotic rate of myocytes can be enhanced by leukemia cell infiltration.

关 键 词：心肌 白血病 凋亡 小鼠 

分 类 号：R733.7[医药卫生—肿瘤] R732.1[医药卫生—临床医学]