血管内皮细胞生长因子在脑星形细胞瘤的表达及其与微血管数的关系  

Expression of vascular endothelial growth factor in brain astrotytoma and its relationship with microvessel quantities

作　　者：穆林森[1] 孙晓东[2] 郎铁成[3] 

机构地区：[1]佳木斯大学2000级外科 [2]大庆石油管理局总医院 [3]佳木斯大学附属第一医院

出　　处：《黑龙江医药科学》2001年第6期22-23,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:研究血管内皮生长因子(VEGF)在脑星形细胞瘤中的表达,探讨VEGF与肿瘤的病理分级、部位、体积、预后的关系,及其与微血管数的关系。方法:应用免疫组化法对60例脑星形细胞瘤的VEGF及微血管数进行检测,结合临床进行定性、定量、定位分析。结果:脑星形细胞瘤中VEGF高表达,并与微血管数相关,VEGF的表达强度及微血管数与肿瘤的病理分级、生存率及某些部位有相关性,而与肿瘤的体积无相关性。结论:VEGF在脑星形细胞瘤微血管生成中起重要作用,VEGF的表达与微血管数均可做为判断肿瘤预后的重要参考指标。Objective: To study the vasscular endothelial growth factor(VEGF) expression and the relationship of VEGF and the pathological grading/ site/volume/prognosis and the microvessel quantities in brain astrocytoma. Methods: The VEGF expression and the microvessel quantities in 60 cases were detected by the sp immunohistochemical method and the qualitative, quantitative and oreentation clinical analyses were made. Results: VEGF was highly expressed in astrocytoma, which was correlated with the microvessel quantities. The VEGF intensity and the microvessel quantities were associated with the pathological grading and survival rate and some sites and not with the volume, Conclusion: VEGF is an important factor in angiogenesis, The VEGF explession and the mirovessel quantities may both serve as indexes for prognosis.

关 键 词：脑星形细胞瘤 血管内皮生长因子 微血管 免疫组化 预后 

分 类 号：R739.41[医药卫生—肿瘤] R730.264[医药卫生—临床医学]