胸腺神经内分泌癌4例及文献复习  

Thymic neuroendocrine carcinoma: a report of 4 cases and review of the literature

作　　者：杨郁[1] 杜薇[2] 熊伟[1] 杨秀萍[1] 邵俊[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022 [2]解放军457医院

出　　处：《诊断病理学杂志》2002年第1期37-39,T009,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨胸腺神经内分泌癌 (TNC)的临床病理特征及鉴别诊断。方法　报道 4例胸腺神经内分泌癌 ,结合文献从临床病理、免疫表型等方面进行探讨。结果　 4例中 3例完全无症状。巨检肿瘤呈结节状 ,切面灰白 ,可有出血坏死。镜检 2例肿瘤组织呈梁索状、器官样排列 ,1例排列类似于梁索状 ,1例呈燕麦细胞样弥漫分布。免疫组化CAM5 2、CK、NSE、Syn、CgA呈阳性表达。结论　胸腺神经内分泌癌具有复杂的组织学特点 ,根据肿瘤组织和细胞的异型性分为高、中、低分化 。Objective To investigate the clinicopathological features of thymic neuroendocrine carcinoma (TNC) and its differential diagnosis. Methods Clinicopathologic analysis and immunohistochemical staining were performed in 4 cases of TNC. Results Age of the patients ranged from 31 to 62 years, and 3 of them were completely asymptomatic. Grossly, the tumors were gray in color with areas of hemorrhage and necrosis. Histologically, 2 cases showed trabecular and organoid patterns, one had trabecula-like pattern and another had diffuse oat cell-like pattern of growth. Immunohistochemically, the tumor cells were positive for CAM5.2, CK, NSE, Syn and CgA. Conclusions TNC has a pleomorphic appearance of histological features with well, moderate and poor-differentiated areas. Immunohistochemical staining is helpful in the differential diagnosis of TNC from other tumors derived from the thymus.

关 键 词：胸腺神经内分泌癌 临床病理 免疫组织化学 TNC 

分 类 号：R736.3[医药卫生—肿瘤]