成纤维细胞生长因子对兔下颌牵张成骨的影响  

Effects of basic fibroblast growth factor on mandibular distraction osteogenesis in rabbits

作　　者：胡静[1] 王志国[1] 高占巍[1] 李继华[1] 王大章[1] 廖运茂[1] 

机构地区：[1]四川大学华西口腔医学院,四川成都610041

出　　处：《临床口腔医学杂志》2002年第1期6-7,共2页Journal of Clinical Stomatology

基　　金：国家自然科学基金 (39970 797);教育部留学回国人员科研启动基金

摘　　要：目的　研究局部应用碱性成纤维细胞生长因子 (bFGF)对兔下颌牵张成骨的影响。方法　成年大耳白兔 8只 ,随机分为A、B两组 ,每组 4只。用自行研制的牵张器延长双侧下颌骨 6mm ,用bFGF(2 0ng/ml)注入A组动物的牵张区 ,不注射bFGF的B组动物作为对照。在牵张结束后 4周处死所有动物 ,取双侧下颌骨标本进行X线和组织学检查。结果　组织学分析结果显示 ,局部给予bFGF的A组动物下颌牵张后新骨生成速度和数量优于B组动物。Objective To study the effects of bFGF on new bone formation during mandibular distraction osteogenesis in rabbits. Methods 8 mature rabbits were randomly divided into group A (n=4) and group B (n=4). Bilateral mandibular osteotomies were performed and the mandibles of 8 rabbits were lengthened 6 mm using a custom made distractor. The group A rabbits were injected with bFGF solution (20 ng/ml) into the distracted region, whereas group B was used as controls. At 4 weeks after end of distraction, all animals were killed and the mandibles specimens were processed for histological analysis. Results The new bone formation of group A treated by bFGF was superior to that of group B after mandibular distraction. Conclusion bFGF appears to be able to accelerate bone formation during mandibular distraction osteogenesis.

关 键 词：牵张成骨 成纤维细胞生长因子 bEGF 新骨形成 下颌骨 

分 类 号：R782.2[医药卫生—口腔医学]