结肠癌患者组织中组织蛋白酶-D活性变化的临床意义  

Clinical Significance of Cathepsin-D Acitivity Change in Tumor Tissue from Colon Carcinoma Patients

作　　者：陈瑜[1] 蔡崇旺[2] 李明仁[3] 盛健[1] 

机构地区：[1]福建医科大学生化教研组,350004 [2]福州市第二医院骨科,350007 [3]福建医科大学附属第一医院肿瘤外科,350005

出　　处：《福建医药杂志》2001年第5期142-144,共3页Fujian Medical Journal

基　　金：福建省教委资助 B类基金项目 ( 98B0 0 3)

摘　　要：目的　探讨结肠癌组织中组织蛋白酶 - D(Cathepsin- D)活性变化的临床意义。方法　检测 5 6例结肠癌样本 (其中伴有局部淋巴结转移 2 4例 )及 30例结肠息肉样本中 Cath- D的活性 ,研究其预后价值。结果　 (1)结肠癌样本中的 Cath- D的活性明显高于结肠息肉样本及对照组织样本 (P<0 .0 1)。 (2 ) 5 6例结肠癌样本中 ,淋巴结阳性样本中的 Cath- D活性明显高于淋巴结阴性者 (P<0 .0 5 )。结论　 Cath- D的活性增高与结肠癌的侵袭和转移关系密切 ,可作为临床上判断结肠癌患者预后的重要指标。Objective Discussed the clinical cignificance of Cathepsin-D acitivity change in tumor tissue from colon carcinoma patients Methods Determination the activity of Cath-D in 56 cases of colon carcinoma(24 cases of node-negative colon carcinoma)and 30 cases of colon begin disease,To study prognostic value of colon cancer.Results (1)The activity of Cath-D with tissue of colon carcinomas were higher than the begin colon disease and the normal colon tissue(P<0.01).(2)In 56 cases of colon carcinomas,the activity of Cath-D in node-positive colon cancer was higher than the node-negative colon cancer(P<0.05).Conclusion Raising activity of Cath-D was relationship between invading and metastasizng.It might be of clinical significance index for judgement prognostic of colon cancer patients.

关 键 词：组织蛋白酶-D 结肠癌 预后 

分 类 号：R735.35[医药卫生—肿瘤]