EAP/LF交替方案治疗进展期胃癌的临床研究  

Clinical Observation of Etoposide, Adriamycin, Cisplatin and Leucovorin, 5-Fluorouracil Alternating Regimen for Patients with Advanced Gastric Cancer

作　　者：杨磊[1] 李睦昭[1] 樊红[2] 周逢麟[1] 赵勤[1] 崔杰[1] 张毓升[1] 古扎努[1] 王菊勇[1] 乔蕾[1] 

机构地区：[1]甘肃省肿瘤医院内一科,甘肃兰州730050 [2]兰州医学院笫二附属医院消化科,甘肃兰州730030

出　　处：《癌症》2001年第12期1411-1415,共5页Chinese Journal of Cancer

摘　　要：目的:探讨EAP/LF交替方案治疗进展期胃癌的疗效。方法:自1994年10月至1999年12月,124例经病理确诊的有可测量病灶的进展期胃癌患者被随机分入EAP/LF组(研究组)和EAP组(对照组),研究组用药为:足叶乙甙(Vp-16)70mg/m2,静滴,d4-6;阿霉素(ADM)15mg/m2,静注,d1,7;顺铂(DDP)20mg/m2,静滴,d2,8;醛氢叶酸(CF)70mg/m2,静滴,d29-33;5-氟尿嘧啶(5-FU)325mg/m2,静滴,d29-33;每8周重复。对照组用药为:Vp-1670mg/m2,静滴,d4-6,d25-27;ADM15mg/m2,静注,d1,7,22,28;DDP30mg/m2,静滴,d2,8,23,29;每8周重复。结果:研究组客观有效率为62.1%,明显优于对照组的48.3%(P=0.032);研究组有效者中位生存期、无进展生存时间分别为20个月、13个月,均明显优于对照组的13个月(P=0.037)、7个月(P=0.007)。两组不良反应主要有白细胞减少、口腔粘膜炎、脱发。结论:调整剂量的EAP/LF交替方案是一疗效确切、安全、对生存有益处的治疗进展期胃癌的优势方案,值得临床进一步研究。Objective: The aim of this study was to search new chemotherapy regimen to improve treatment for the patients with advanced gastric cancer. Methods: One hundred and twenty four evaluable patients from October 1994 to December 1999 with advanced measurable gastric carcinoma were involved in this study.They were randomly assigned into two groups: Sixty six cases in study group received Etoposide, Adriamycin, Cisplatin and Leucovorin, 5 Fluorouracil (EAP/LF) alternating regimen: Etoposide 70mg/m2,iv.on d4,5,6;Adriamycin 15 mg/m2,iv.on d1,7; Cisplatin 20 mg/m2, iv.on d2,8; Leucovorin 70 mg/m2, iv.on d29-33; and 5 Fluorouracil 325 mg/m2, iv.on d29-33, repeated every 8 weeks. Fifty eight cases in control group received Etoposide, Adriamycin, Cisplatin (EAP) regimen: Etoposide 70 mg/m2, iv.on d4,5,6,25,26,27; Adriamycin 15 mg/m2, iv.on d1,7,22,28; Cisplatin 30 mg/m2,iv.on d2,8,23,29;repeated every 8 weeks. Results: The response was 62.1% in testing group and 48.3% in control group (P=0.032). The median survival time and time to tumor progression were 20 months, and 13 months in testing group, and 13 months and 7 months in control group,respectively (P=0.037; P=0.007). The side effects were leucocytopenia,oral mucositis, and alopecia. Conclusion: The result of this investigation revealed that the EAP/LF alternating regimen is effective and secure. It prolongs the survival time of patients with advanced gastric cancer.

关 键 词：化学疗法 胃肿瘤 足叶乙甙 阿霉素 醛氢叶酸 5-氟尿嘧啶 

分 类 号：R735.2[医药卫生—肿瘤]