胆必清颗粒对急性胆管炎家兔血PL、WBC、AKP及形态学改变的影响  

The effects of Danbiqing granule on blood PL,WBC,AKP and morphologic changes in acute cholangitis rabbits

作　　者：郑尧[1] 王宏波[2] 公衍玲[1] 孟林[1] 马德禄[1] 林秀珍[1] 

机构地区：[1]天津医科大学药理教研室,300070 [2]山东省即墨市人民医院普外科

出　　处：《天津医科大学学报》2001年第4期468-468,477,共2页Journal of Tianjin Medical University

基　　金：天津市自然科学基金95重点攻关项目资助 (编号 :983113411)

摘　　要：目的 :观察胆必清颗粒对实验性急性胆管炎的防治作用。方法 :建立家兔急性细菌性胆管炎模型 ,用直接镜检法计数血小板 (PL)、白细胞 (WBC) ,磷酸苯二钠法测定血清碱性磷酸酶 (AKP)总活力 ,对其手术前后的变化进行比较 ,病理检查肝组织形态学改变。结果 :胆管炎模型组手术后与手术前比较 ,血PL计数显著降低 ,WBC计数和AKP活力明显升高 ,其差值变化与手术对照组比较有显著性差异 (P<0.01) ,病理检查显示肝组织和肝内胆管存在明显炎性改变 ;各胆必清组均能不同程度地抑制上述指标的变化 (P<0.05) ,改善形态学损害。结论Objective: To observe the preventive and therapeutic effects of Danbiqing Granule on acute bacterial cholangitis. Methods: Acute bacterial cholangitis model of rabbit was established.Blood PL,WBC counts were measured directly under the microscope.Serum AKP activity was measured by a method of disodium phenyl orthophosphate. And their changes between postoperation and preoperation were compared. The morphologic changes of liver tissue was also observed.Results: After operation ,blood PL decreased and WBC and AKP activity was increased markedly in cholangitis group compared with preoperation,and their changes had statistical significance compared with control group(P<0.01).Significant inflammatory changes were also observed in liver tissue and biliferous ducts.Danbiqing inhibited these changes in a different degree(P<0.05),and alleviated the morphologic injury. Conclusion: Danbiqing granule has good preventive and therapeutic effects on acute bacterial cholangitis in rabbits.

关 键 词：胆必清 胆管炎 PL WBC AKP 胆必清颗粒 

分 类 号：R575.7[医药卫生—消化系统]