氟西汀与多塞平治疗抑郁症疗效观察  

Efficacy and side effects of fluoxetine and doxepin in depressed patients.

作　　者：孙树花[1] 史青[1] 张陆云[1] 

机构地区：[1]山东省滨州市人民医院精神卫生中心,256613

出　　处：《山东精神医学》2001年第4期229-230,共2页Shangdong Archives of Psychiatry

摘　　要：目的 比较氟西汀与多塞平治疗抑郁症的疗效与不良反应。方法 60例符合CCMD-2-R诊断标准的抑郁症患者,HAMD评分≥18,经6周随机、双育对照研究并给予HAMD、CGI、TESS量表及临床疗效评估。结果 氟西汀组显效率73.3％,多塞平组显效率63.3％,两者无显著性差异。氟西汀不良反应较多塞平少而轻。结论 氟西汀治疗抑郁症疗效确切,不良反应轻微。Objective To compare the efficacy and side effects of fluoxetine and doxepin.Methods Sixty patients with major depress (CCMD-Ⅱ-R) were recruited for six weeks doubleblind randomized trial comparing the efficacy and side effects of fluxoxetine and doxepin.Improvement and side effects were monitored with clinical evalusion, HAMD, CGI and TESS.Results There was no significant difference in the efficacy between fluoxetine and doxepin.The response rate was 73.3% and 63.3% for fluoxetine and doxepin respectively.Patients who were on fluoxetine reported less and slighter side effects.Conclusion Fluoxetine is an effective and well tolerated antidepressant.

关 键 词：氟西汀 多塞平 抑郁症 治疗 

分 类 号：R749.405[医药卫生—神经病学与精神病学]