恶性成釉细胞瘤细胞增殖活性和分化的研究  

Proliferation and differentiation of malignant ameloblastoma

作　　者：刘进忠[1] 汪说之[1] 陈新明[1] 

机构地区：[1]武汉大学口腔医学院,430079

出　　处：《实用口腔医学杂志》2001年第5期388-390,共3页Journal of Practical Stomatology

基　　金：湖北省卫生厅资助课题编号 :W9742 3

摘　　要：目的 :研究恶性成釉细胞瘤细胞增殖活性和分化特点。方法 :应用免疫组化 SP方法检测 17例恶性成釉细胞瘤组织中 PCNA、Ki- 67、CK19以及 CK10和 13蛋白的表达。结果 :PCNA和 Ki- 67在恶性成釉细胞瘤中的增殖指数显著高于良性成釉细胞瘤 ( P<0 .0 5 )。 CK10和 13在恶性成釉细胞瘤的阳性表达率显著低于良性成釉细胞瘤 ( P<0 .0 5 )。而 CK19在良恶性成釉细胞瘤的阳性表达率无显著性差异。结论 :恶性成釉细胞瘤细胞增殖活性高于良性成釉细胞瘤 ,CK10和 13的阳性表达率有助于恶性成釉细胞瘤的诊断。砄bjective:To study the characteristics of proliferation and differentiation of malignant ameloblastoma.Methods:The expression of PCNA,Ki 67, CK19 and CK10 and CK13 proteins in 17 cases of malignant ameloblastoma was detected immunohistochemically by SP method. Results: The proliferating indices of PCNA and Ki 67 were significantly higher in malignant ameloblastoma than those in benign ameloblastoma ( P <0.05). The positive cells of CK10 and CK 13 in malignant ameloblastoma were significantly lower than in benign ameloblastom( P <0.05).No difference was found in the expression of CK19 between malignant and benign ameloblastoma. Conclusion: Malignant ameloblastoma demonstrates a higher proliferating activity than benign ameloblastoma.

关 键 词：牙源性肿瘤 成釉细胞瘤 细胞分化 

分 类 号：R739.82[医药卫生—肿瘤]