刺梨对衰老小鼠肝细胞线粒体损伤保护作用的体视学研究  

A stereologic study on protective effect of Rosa roxburghii Trait on mitochondria damage of liver cell of aging model mice

作　　者：罗素元[1] 谭兵兵[1] 廖吉文[1] 罗利红 

机构地区：[1]遵义医学院生物学教研室,563003 [2]贵州省赤水市中医院,564700

出　　处：《贵州医药》2001年第11期980-981,共2页Guizhou Medical Journal

摘　　要：目的观察刺梨对D -半乳糖致衰老小鼠肝细胞线粒体损伤的保护作用。方法小鼠颈背部皮下注射D -半乳糖建立衰老模型 ,同时刺梨保护组灌服刺梨汁 ,36天后取肝脏制备透射电镜样品 ,对肝细胞线粒体采用体视学中体密度 (Vv)、面数密度 (NA)指标进行分析。结果刺梨保护组肝细胞线粒体体密度、面数密度与正常对照组接近 ,而明显高于衰老模型组 (P <0 0 1、P <0 0 5 )。结论刺梨对D -半乳糖致衰老小鼠肝细胞线粒体的损伤具有保护作用。Objective To investigate the protective effect of Rosa roxburghii Trait on mitochondria damage of liver cell of aging model mice.Methods D-galactose was given S.C. to mice to induce aging model. Rosa roxburghii Trait juice was administrated for 36 days. The livers were observed by transmission electronic microscope, Vv and N A of mitochondria in liver cell were measured. Results V vand N A of mitochondria of Rosa roxburgii Trait group were higher than that of aging model group ( P <0 01? P <0 05),there was no significace between Rosa roxburghii Trait group and control group.Conclusion Rosa roxburghii Trait has a protective effect on mitochondria damage of liver of aging model mice caused by D-galactose.

关 键 词：刺梨 衰老 肝脏 体视学 动物实验 肝细胞线体损伤 保护作用 

分 类 号：R282.710.5[医药卫生—中药学]