类肿瘤型舍格伦综合征46例临床分析  

The Analysis and Discussion of Clinical Features and Treatment of Tumor-like Sjgren's Syndrome in 46 Cases

作　　者：俞创奇[1] 胡北平[1] 郑凌艳[1] 丁永敏[1] 

机构地区：[1]上海第二医科大学附属第九人民医院口腔医学院口腔颌面外科,上海200011

出　　处：《上海口腔医学》2001年第4期302-304,共3页Shanghai Journal of Stomatology

摘　　要：目的　通过临床资料分析 ,进一步探讨类肿瘤型舍格伦综合征的临床表现和治疗方法。方法　结合文献复习 ,对 46例类肿瘤型舍格伦综合征的临床表现和治疗方法进行回顾性分析。结果　 46例患者的局部表现主要为1个或 1个以上肿块。伴有口干症 19例 (4 1% ) ,眼干症 11例 (2 3% ) ,有自身抗体 8例 (17% )。治疗结果 ,手术组 2 5例全部有效 ,但有 5例异位复发 ;药物组 2 1例 ,有效 17例 ,有 8例原位复发。手术组有 1例、药物组 2例于治疗后随访中出现恶变。结论　类肿瘤型舍格伦综合征局部表现主要为肿块 ,部分患者有全身表现。少数可发生恶变。治疗应采取局部与全身、药物与手术相结合的方法。治疗前明确诊断 ,首选药物治疗 ,若疗效不明显或反复出现肿块 ,宜及时手术治疗。Objective Manifestations and treatment of tumor-like Sjgren's syndrome(SS) is varying , it is difficulty to differentiate it from other diseases. The purpose of this paper was to identify the peculiarity of the manifestations and treatment of tumor-like SS.Methods The data of 46 cases suffering from tumor-like SS had been analyzed retrospectively, and discussed with published articles about its clinical features and treatment.Results There were one or more than one masses in salivary gland, general manifestations were found in 46 cases, dry mouth 41%, dry eye 23%, autoantibody 17%. The result of treatment showed recurrence site of operation group was out of primary region, recurrence rate was 20%.Effective rate of drug group was about 81%,however, recurrence rate was up to 38%.Malignant change occurred in three cases.Conclusion The local feature of tumor-like SS is mass in salivary gland, general manifestations are accompanied in some patients. It presents chronic benign process, malignant change may occur in a few patients. Combined therapy should be taken reasonably, local with general, drug with operation. The diagnosis should be identified before treatment, drug therapy is used at first, and operation is adopted after failure of drug treatment.

关 键 词：舍格伦综合征 唾液腺 诊断 治疗 

分 类 号：R782.7[医药卫生—口腔医学]