神经营养因子参与帕金森病的发生及治疗中的潜在作用  

The potential role of neurotrophic factor in the pathogenesis and therapy of Parkinson's disease

作　　者：刘爽[1] 王亚奇[1] 

机构地区：[1]海军总医院神经外科病理实验室,北京100037

出　　处：《中国病理生理杂志》2002年第1期101-103,107,共4页Chinese Journal of Pathophysiology

基　　金：海军课题资助项目 (No .0 0 3317)

摘　　要：Parkinson’s disease is characterized by degeneration and dysfunction of dopaminergic neurons in the mid-brain substantia nigra, neurons that project to the caudate putamen. The clinical symptoms are caused by the loss of dopamine and the consequent dysfunction of the nigrostriatal pathway. Neurotrophic factors that may prevent nigrostriatal degeneration by improving the function of remaining dopaminergic neurons has the potential to be a useful therapy for Parkinson’s disease. Neurotrophic factors and their specific receptors could play an important role in the progress of Parkinson’s disease. The neuroprotective effects of neurotrophic factors GDNF, BDNF, IL-6 on dopaminergic neurons in vivo and in vitro , and the potential therapeutic use in treating Parkinson’s disease were discussed in this paper.Parkinson's disease is characterized by degeneration and dysfunction of dopaminergic neurons in the mid-brain substantia nigra, neurons that project to the caudate putamen. The clinical symptoms are caused by the loss of dopamine and the consequent dysfunction of the nigrostriatal pathway. Neurotrophic factors that may prevent nigrostriatal degeneration by improving the function of remaining dopaminergic neurons has the potential to be a useful therapy for Parkinson's disease. Neurotrophic factors and their specific receptors could play an important role in the progress of Parkinson's disease. The neuroprotective effects of neurotrophic factors GDNF, BDNF, IL-6 on dopaminergic neurons in vivo and in vitro , and the potential therapeutic use in treating Parkinson's disease were discussed in this paper.

关 键 词：帕金森病 神经营养因子 白细胞介素6 

分 类 号：R742.5[医药卫生—神经病学与精神病学]