茶多酚、维生素C对染石英尘大鼠氧化损伤的缓解作用  

Study of Tea Polyphenols,Vitamin C on Oxidative Damage Induced by Silica in Rats

作　　者：张艳淑[1] 姚林[1] 刘英莉[1] 王广增[1] 赵伯阳[1] 鲍运林 

机构地区：[1]华北煤炭医学院预防医学系,唐山063000 [2]江苏省东海县卫生防疫站,东海222500

出　　处：《劳动医学》2001年第4期215-216,共2页

基　　金：原煤炭部科研基金项目 (安 95 466)

摘　　要：[目的 ]探讨抗氧化剂茶多酚、维生素C对染尘大鼠血液中一氧化氮及抗氧化酶活性的影响。 [方法 ]Wistar大鼠随机分成对照组、石英粉尘组及预防组 (茶多酚组 ,茶多酚 +VitC组 )。检测实验大鼠血液中NO和NOS、SOD、GSH Px的活性。 [结果 ]与石英粉尘组比较 ,预防组大鼠血液中NO的含量及NOS活性下降 ,SOD、GSH Px活性上升。 [结论 ]抗氧化剂茶多酚。Objectives] This study is to investigate the effects of tea polyphenols (TP) and vitamin C on oxidative damage in rats. The rats were randomly divided into three groups-physiological saline group,silica group and preventive group (including TP and TP+Vit C subgroups). The level of NO and the activities of NOS,SOD GSH Px were determined. The level of NO,and the activities of NOS in preventive groups were significantly decreased compared with those in silica group,the activities of SOD and GSH Px increased. [Conclusions] TP,Vit C can prevent oxidation damage of lung induced by silica in a certain degree.

关 键 词：石英粉尘 茶多酚 氧化损伤 

分 类 号：R135.2[医药卫生—劳动卫生]